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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells
|
|---|---|
| Published in |
Nature Biotechnology, February 2011
|
| DOI | 10.1038/nbt.1788 |
| Pubmed ID | |
| Authors |
Michael D Green, Antonia Chen, Maria-Cristina Nostro, Sunita L d'Souza, Christoph Schaniel, Ihor R Lemischka, Valerie Gouon-Evans, Gordon Keller, Hans-Willem Snoeck |
| Abstract |
Directed differentiation of human embryonic stem (hES) cells and human induced pluripotent stem (hiPS) cells captures in vivo developmental pathways for specifying lineages in vitro, thus avoiding perturbation of the genome with exogenous genetic material. Thus far, derivation of endodermal lineages has focused predominantly on hepatocytes, pancreatic endocrine cells and intestinal cells. The ability to differentiate pluripotent cells into anterior foregut endoderm (AFE) derivatives would expand their utility for cell therapy and basic research to tissues important for immune function, such as the thymus; for metabolism, such as thyroid and parathyroid; and for respiratory function, such as trachea and lung. We find that dual inhibition of transforming growth factor (TGF)-β and bone morphogenic protein (BMP) signaling after specification of definitive endoderm from pluripotent cells results in a highly enriched AFE population that is competent to be patterned along dorsoventral and anteroposterior axes. These findings provide an approach for the generation of AFE derivatives. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 348 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 1% |
| Brazil | 3 | <1% |
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| Germany | 1 | <1% |
| Portugal | 1 | <1% |
| Australia | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 333 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 89 | 26% |
| Student > Ph. D. Student | 82 | 24% |
| Student > Master | 33 | 9% |
| Student > Bachelor | 33 | 9% |
| Professor > Associate Professor | 17 | 5% |
| Other | 45 | 13% |
| Unknown | 49 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 125 | 36% |
| Biochemistry, Genetics and Molecular Biology | 71 | 20% |
| Medicine and Dentistry | 46 | 13% |
| Engineering | 16 | 5% |
| Immunology and Microbiology | 9 | 3% |
| Other | 23 | 7% |
| Unknown | 58 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#732,178
of 23,804,991 outputs
Outputs from Nature Biotechnology
#1,469
of 8,434 outputs
Outputs of similar age
#2,474
of 110,508 outputs
Outputs of similar age from Nature Biotechnology
#6
of 53 outputs
Altmetric has tracked 23,804,991 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,434 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.2. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 110,508 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.