Title |
Brain white matter microstructure alterations in adolescent rhesus monkeys exposed to early life stress: associations with high cortisol during infancy
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Published in |
Biology of Mood & Anxiety Disorders, December 2013
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DOI | 10.1186/2045-5380-3-21 |
Pubmed ID | |
Authors |
Brittany R Howell, Kai M McCormack, Alison P Grand, Nikki T Sawyer, Xiaodong Zhang, Dario Maestripieri, Xiaoping Hu, Mar M Sanchez |
Abstract |
Early adverse experiences, especially those involving disruption of the mother-infant relationship, are detrimental for proper socioemotional development in primates. Humans with histories of childhood maltreatment are at high risk for developing psychopathologies including depression, anxiety, substance abuse, and behavioral disorders. However, the underlying neurodevelopmental alterations are not well understood. Here we used a nonhuman primate animal model of infant maltreatment to study the long-term effects of this early life stress on brain white matter integrity during adolescence, its behavioral correlates, and the relationship with early levels of stress hormones. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
United States | 2 | 1% |
Canada | 1 | <1% |
Netherlands | 1 | <1% |
Japan | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 132 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 23% |
Researcher | 28 | 20% |
Student > Master | 14 | 10% |
Student > Bachelor | 12 | 9% |
Student > Doctoral Student | 10 | 7% |
Other | 17 | 12% |
Unknown | 27 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 32 | 23% |
Psychology | 30 | 21% |
Agricultural and Biological Sciences | 17 | 12% |
Medicine and Dentistry | 14 | 10% |
Social Sciences | 5 | 4% |
Other | 5 | 4% |
Unknown | 37 | 26% |