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Proximal aortic stiffening in Turner patients may be present before dilation can be detected: a segmental functional MRI study

Overview of attention for article published in Critical Reviews in Diagnostic Imaging, February 2017
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Title
Proximal aortic stiffening in Turner patients may be present before dilation can be detected: a segmental functional MRI study
Published in
Critical Reviews in Diagnostic Imaging, February 2017
DOI 10.1186/s12968-017-0331-0
Pubmed ID
Authors

Daniel G. H. Devos, Katya De Groote, Danilo Babin, Laurent Demulier, Yves Taeymans, Jos J. Westenberg, Luc Van Bortel, Patrick Segers, Eric Achten, Jean De Schepper, Ernst Rietzschel

Abstract

To study segmental structural and functional aortic properties in Turner syndrome (TS) patients. Aortic abnormalities contribute to increased morbidity and mortality of women with Turner syndrome. Cardiovascular magnetic resonance (CMR) allows segmental study of aortic elastic properties. We performed Pulse Wave Velocity (PWV) and distensibility measurements using CMR of the thoracic and abdominal aorta in 55 TS-patients, aged 13-59y, and in a control population (n = 38;12-58y). We investigated the contribution of TS on aortic stiffness in our entire cohort, in bicuspid (BAV) versus tricuspid (TAV) aortic valve-morphology subgroups, and in the younger and older subgroups. Differences in aortic properties were only seen at the most proximal aortic level. BAV Turner patients had significantly higher PWV, compared to TAV Turner (p = 0.014), who in turn had significantly higher PWV compared to controls (p = 0.010). BAV Turner patients had significantly larger ascending aortic (AA) luminal area and lower AA distensibility compared to both controls (all p < 0.01) and TAV Turner patients. TAV Turner had similar AA luminal areas and AA distensibility compared to Controls. Functional changes are present in younger and older Turner subjects, whereas ascending aortic dilation is prominent in older Turner patients. Clinically relevant dilatation (TAV and BAV) was associated with reduced distensibility. Aortic stiffening and dilation in TS affects the proximal aorta, and is more pronounced, although not exclusively, in BAV TS patients. Functional abnormalities are present at an early age, suggesting an aortic wall disease inherent to the TS. Whether this increased stiffness at young age can predict later dilatation needs to be studied longitudinally.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Other 5 13%
Professor > Associate Professor 3 8%
Student > Master 3 8%
Student > Postgraduate 2 5%
Other 7 18%
Unknown 12 31%
Readers by discipline Count As %
Medicine and Dentistry 14 36%
Engineering 4 10%
Social Sciences 2 5%
Sports and Recreations 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 5%
Unknown 15 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2018.
All research outputs
#23,069,091
of 25,711,518 outputs
Outputs from Critical Reviews in Diagnostic Imaging
#1,293
of 1,386 outputs
Outputs of similar age
#374,138
of 434,072 outputs
Outputs of similar age from Critical Reviews in Diagnostic Imaging
#34
of 34 outputs
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