Title |
Efficacy and safety of rituximab treatment in early primary Sjögren's syndrome: a prospective, multi-center, follow-up study
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Published in |
Arthritis Research & Therapy, October 2013
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DOI | 10.1186/ar4359 |
Pubmed ID | |
Authors |
Francesco Carubbi, Paola Cipriani, Alessandra Marrelli, Paola Di Benedetto, Piero Ruscitti, Onorina Berardicurti, Ilenia Pantano, Vasiliki Liakouli, Saverio Alvaro, Alessia Alunno, Antonio Manzo, Francesco Ciccia, Roberto Gerli, Giovanni Triolo, Roberto Giacomelli |
Abstract |
Primary Sjögren's syndrome (pSS) is an autoimmune disorder affecting exocrine glands; however, a subgroup of pSS patients experience systemic extra-glandular involvement leading to a worsening of disease prognosis. Current therapeutic options are mainly empiric and often translated by other autoimmune diseases. In the last few years growing evidence suggests that B-cell depletion by rituximab (RTX) is effective also in pSS. Patients with early active disease appear to be those who could benefit the most from RTX. The aim of this study was to investigate the efficacy and safety of RTX in comparison to disease modifying anti-rheumatic drugs (DMARDs) in early active pSS patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 4 | 31% |
United States | 2 | 15% |
India | 1 | 8% |
Ecuador | 1 | 8% |
United Kingdom | 1 | 8% |
South Africa | 1 | 8% |
Bulgaria | 1 | 8% |
Unknown | 2 | 15% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 62% |
Practitioners (doctors, other healthcare professionals) | 3 | 23% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Switzerland | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Unknown | 119 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 19% |
Researcher | 14 | 11% |
Student > Master | 14 | 11% |
Student > Bachelor | 13 | 10% |
Other | 13 | 10% |
Other | 25 | 20% |
Unknown | 21 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 61 | 49% |
Agricultural and Biological Sciences | 10 | 8% |
Biochemistry, Genetics and Molecular Biology | 5 | 4% |
Immunology and Microbiology | 3 | 2% |
Psychology | 3 | 2% |
Other | 11 | 9% |
Unknown | 31 | 25% |