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The Molecular Biology of Down Syndrome

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Cover of 'The Molecular Biology of Down Syndrome'

Table of Contents

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    Book Overview
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    Chapter 1 Molecular abnormalities of the brain in Down Syndrome: relevance to Alzheimer’s neurodegeneration
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    Chapter 2 Reduced aldehyde dehydrogenase levels in the brain of patients with Down Syndrome
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    Chapter 3 The Down Syndrome critical region
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    Chapter 4 Neuropathology
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    Chapter 5 c-fos expression in brains of patients with Down Syndrome
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    Chapter 6 Neuronal cell death in Down’s syndrome
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    Chapter 7 Altered gene expression in fetal Down Syndrome brain as revealed by the gene hunting technique of subtractive hybridization
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    Chapter 8 Gene expression in fetal Down Syndrome brain as revealed by subtractive hybridization
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    Chapter 9 Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration
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    Chapter 10 Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer’s disease brain is downregulated at the mRNA and dysregulated at the protein level
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    Chapter 11 Gene expression relevant to Down Syndrome: problems and approaches
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    Chapter 12 Isolation and analysis of chromosome 21 genes potentially involved in Down Syndrome
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    Chapter 13 Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down Syndrome
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    Chapter 14 Serotonin (5-HT) in brains of adult patients with Down Syndrome
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    Chapter 15 Mechanisms of neuronal death in Down’s syndrome
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    Chapter 16 Impaired brain glucose metabolism in patients with Down Syndrome
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    Chapter 17 Oxidative stress and neural dysfunction in Down syndrome.
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    Chapter 18 Expression of the transcription factor ETS2 in brain of patients with Down Syndrome—evidence against the overexpression-gene dosage hypothesis
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    Chapter 19 Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome
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    Chapter 20 The “gene dosage effect” hypothesis versus the “amplified developmental instability” hypothesis in Down syndrome
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    Chapter 21 Downregulation of the transcription factor scleraxis in brain of patients with Down Syndrome
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    Chapter 22 Heat-shock protein 70 levels in brain of patients with Down Syndrome and Alzheimer’s disease
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    Chapter 23 Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer’s disease and Down Syndrome
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    Chapter 24 Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin
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    Chapter 25 Overexpression of DNAse I in brain of patients with Down Syndrome
Attention for Chapter 16: Impaired brain glucose metabolism in patients with Down Syndrome
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Chapter title
Impaired brain glucose metabolism in patients with Down Syndrome
Chapter number 16
Book title
The Molecular Biology of Down Syndrome
Published in
Journal of neural transmission Supplementum, January 1999
DOI 10.1007/978-3-7091-6380-1_16
Pubmed ID
Book ISBNs
978-3-21-183377-3, 978-3-70-916380-1
Authors

O. Labudova, N. Cairns, E. Kitzmüller, G. Lubec, Labudova, O., Cairns, N., Kitzmüller, E., Lubec, G.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 10%
Unknown 19 90%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 19%
Researcher 3 14%
Student > Bachelor 2 10%
Professor 2 10%
Student > Ph. D. Student 2 10%
Other 4 19%
Unknown 4 19%
Readers by discipline Count As %
Medicine and Dentistry 7 33%
Neuroscience 3 14%
Psychology 3 14%
Biochemistry, Genetics and Molecular Biology 2 10%
Agricultural and Biological Sciences 1 5%
Other 0 0%
Unknown 5 24%