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Oxacillin Alters the Toxin Expression Profile of Community-Associated Methicillin-Resistant Staphylococcus aureus

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, December 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
3 news outlets
twitter
2 tweeters

Citations

dimensions_citation
37 Dimensions

Readers on

mendeley
64 Mendeley
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Title
Oxacillin Alters the Toxin Expression Profile of Community-Associated Methicillin-Resistant Staphylococcus aureus
Published in
Antimicrobial Agents and Chemotherapy, December 2013
DOI 10.1128/aac.01618-13
Pubmed ID
Authors

Justine K. Rudkin, Maisem Laabei, Andrew M. Edwards, Hwang-Soo Joo, Michael Otto, Katrina L. Lennon, James P. O'Gara, Nicholas R. Waterfield, Ruth C. Massey

Abstract

The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a growing cause for concern. These strains are more virulent than health care-associated MRSA (HA-MRSA) due to higher levels of toxin expression. In a previous study, we showed that the high-level expression of PBP2a, the alternative penicillin binding protein encoded by the mecA gene on type II staphylococcal cassette chromosome mec (SCCmec) elements, reduced toxicity by interfering with the Agr quorum sensing system. This was not seen in strains carrying the CA-MRSA-associated type IV SCCmec element. These strains express significantly lower levels of PBP2a than the other MRSA type, which may explain their relatively high toxicity. We hypothesized that as oxacillin is known to increase mecA expression levels, it may be possible to attenuate the toxicity of CA-MRSA by using this antibiotic. Subinhibitory oxacillin concentrations induced PBP2a expression, repressed Agr activity, and, as a consequence, decreased phenol-soluble modulin (PSM) secretion by CA-MRSA strains. However, consistent with other studies, oxacillin also increased the expression levels of alpha-toxin and Panton-Valentine leucocidin (PVL). The net effect of these changes on the ability to lyse diverse cell types was tested, and we found that where the PSMs and alpha-toxin are important, oxacillin reduced overall lytic activity, but where PVL is important, it increased lytic activity, demonstrating the pleiotropic effect of oxacillin on toxin expression by CA-MRSA.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Ireland 1 2%
Australia 1 2%
Unknown 61 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 25%
Researcher 13 20%
Student > Master 10 16%
Student > Doctoral Student 6 9%
Other 2 3%
Other 8 13%
Unknown 9 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 41%
Biochemistry, Genetics and Molecular Biology 10 16%
Medicine and Dentistry 6 9%
Immunology and Microbiology 4 6%
Veterinary Science and Veterinary Medicine 2 3%
Other 3 5%
Unknown 13 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2013.
All research outputs
#712,211
of 14,123,042 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#318
of 11,987 outputs
Outputs of similar age
#13,008
of 254,074 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#5
of 169 outputs
Altmetric has tracked 14,123,042 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,987 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 254,074 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.