| Title |
Conserved RNA Helicase FRH Acts Nonenzymatically to Support the Intrinsically Disordered Neurospora Clock Protein FRQ
|
|---|---|
| Published in |
Molecular Cell, December 2013
|
| DOI | 10.1016/j.molcel.2013.11.005 |
| Pubmed ID | |
| Authors |
Jennifer M. Hurley, Luis F. Larrondo, Jennifer J. Loros, Jay C. Dunlap |
| Abstract |
Protein conformation dictates a great deal of protein function. A class of naturally unstructured proteins, termed intrinsically disordered proteins (IDPs), demonstrates that flexibility in structure can be as important mechanistically as rigid structure. At the core of the circadian transcription/translation feedback loop in Neurospora crassa is the protein FREQUENCY (FRQ), shown here shown to share many characteristics of IDPs. FRQ in turn binds to FREQUENCY-Interacting RNA Helicase (FRH), whose clock function has been assumed to relate to its predicted helicase function. However, mutational analyses reveal that the helicase function of FRH is not essential for the clock, and a region of FRH distinct from the helicase region is essential for stabilizing FRQ against rapid degradation via a pathway distinct from its typical ubiquitin-mediated turnover. These data lead to the hypothesis that FRQ is an IDP and that FRH acts nonenzymatically, stabilizing FRQ to enable proper clock circuitry/function. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| France | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 2% |
| Unknown | 60 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 26% |
| Student > Bachelor | 10 | 16% |
| Student > Doctoral Student | 7 | 11% |
| Researcher | 7 | 11% |
| Student > Master | 4 | 7% |
| Other | 7 | 11% |
| Unknown | 10 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 24 | 39% |
| Agricultural and Biological Sciences | 20 | 33% |
| Chemistry | 2 | 3% |
| Medicine and Dentistry | 1 | 2% |
| Energy | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 11 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2018.
All research outputs
#7,960,512
of 25,374,647 outputs
Outputs from Molecular Cell
#5,210
of 7,617 outputs
Outputs of similar age
#87,926
of 320,227 outputs
Outputs of similar age from Molecular Cell
#45
of 75 outputs
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