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A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt(II), Zn(II), Cu(II), and Co(III) Complexes withN-heteroaromatic Schiff Base (E)-2-[N′-(1-pyridin-2-yl-ethylidene…

Overview of attention for article published in Journal of Biochemical & Molecular Toxicology, December 2013
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Title
A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt(II), Zn(II), Cu(II), and Co(III) Complexes withN-heteroaromatic Schiff Base (E)-2-[N′-(1-pyridin-2-yl-ethylidene)hydrazino]acetate
Published in
Journal of Biochemical & Molecular Toxicology, December 2013
DOI 10.1002/jbt.21541
Pubmed ID
Authors

Nenad R. Filipović, Ivanka Marković, Dragana Mitić, Natalija Polović, Miloš Milčić, Marija Dulović, Maja Jovanović, Milena Savić, Miomir Nikšić, Katarina Anđelković, Tamara Todorović

Abstract

In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N'-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 22%
Researcher 3 17%
Professor > Associate Professor 3 17%
Professor 2 11%
Student > Bachelor 1 6%
Other 3 17%
Unknown 2 11%
Readers by discipline Count As %
Chemistry 4 22%
Biochemistry, Genetics and Molecular Biology 3 17%
Medicine and Dentistry 3 17%
Agricultural and Biological Sciences 2 11%
Immunology and Microbiology 1 6%
Other 2 11%
Unknown 3 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2013.
All research outputs
#10,799,039
of 12,179,847 outputs
Outputs from Journal of Biochemical & Molecular Toxicology
#166
of 227 outputs
Outputs of similar age
#173,305
of 209,369 outputs
Outputs of similar age from Journal of Biochemical & Molecular Toxicology
#1
of 2 outputs
Altmetric has tracked 12,179,847 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 227 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,369 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them