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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Overview of attention for article published in PLoS Genetics, April 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
22 news outlets
blogs
2 blogs
twitter
65 tweeters
facebook
8 Facebook pages
reddit
1 Redditor

Citations

dimensions_citation
88 Dimensions

Readers on

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300 Mendeley
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4 CiteULike
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Title
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Published in
PLoS Genetics, April 2017
DOI 10.1371/journal.pgen.1006528
Pubmed ID
Authors

Mariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary F. Feitosa, Llilda Barata, Thomas W. Winkler, Audrey Y. Chu, Anubha Mahajan, David Hadley, Luting Xue, Tsegaselassie Workalemahu, Nancy L. Heard-Costa, Marcel den Hoed, Tarunveer S. Ahluwalia, Qibin Qi, Julius S. Ngwa, Frida Renström, Lydia Quaye, John D. Eicher, James E. Hayes, Marilyn Cornelis, Zoltan Kutalik, Elise Lim, Jian’an Luan, Jennifer E. Huffman, Weihua Zhang, Wei Zhao, Paula J. Griffin, Toomas Haller, Shafqat Ahmad, Pedro M. Marques-Vidal, Stephanie Bien, Loic Yengo, Alexander Teumer, Albert Vernon Smith, Meena Kumari, Marie Neergaard Harder, Johanne Marie Justesen, Marcus E. Kleber, Mette Hollensted, Kurt Lohman, Natalia V. Rivera, John B. Whitfield, Jing Hua Zhao, Heather M. Stringham, Leo-Pekka Lyytikäinen, Charlotte Huppertz, Gonneke Willemsen, Wouter J. Peyrot, Ying Wu, Kati Kristiansson, Ayse Demirkan, Myriam Fornage, Maija Hassinen, Lawrence F. Bielak, Gemma Cadby, Toshiko Tanaka, Reedik Mägi, Peter J. van der Most, Anne U. Jackson, Jennifer L. Bragg-Gresham, Veronique Vitart, Jonathan Marten, Pau Navarro, Claire Bellis, Dorota Pasko, Åsa Johansson, Søren Snitker, Yu-Ching Cheng, Joel Eriksson, Unhee Lim, Mette Aadahl, Linda S. Adair, Najaf Amin, Beverley Balkau, Juha Auvinen, John Beilby, Richard N. Bergman, Sven Bergmann, Alain G. Bertoni, John Blangero, Amélie Bonnefond, Lori L. Bonnycastle, Judith B. Borja, Søren Brage, Fabio Busonero, Steve Buyske, Harry Campbell, Peter S. Chines, Francis S. Collins, Tanguy Corre, George Davey Smith, Graciela E. Delgado, Nicole Dueker, Marcus Dörr, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Jessica D. Faul, Mao Fu, Kristine Færch, Christian Gieger, Sven Gläser, Jian Gong, Penny Gordon-Larsen, Harald Grallert, Tanja B. Grammer, Niels Grarup, Gerard van Grootheest, Kennet Harald, Nicholas D. Hastie, Aki S. Havulinna, Dena Hernandez, Lucia Hindorff, Lynne J. Hocking, Oddgeir L. Holmens, Christina Holzapfel, Jouke Jan Hottenga, Jie Huang, Tao Huang, Jennie Hui, Cornelia Huth, Nina Hutri-Kähönen, Alan L. James, John-Olov Jansson, Min A. Jhun, Markus Juonala, Leena Kinnunen, Heikki A. Koistinen, Ivana Kolcic, Pirjo Komulainen, Johanna Kuusisto, Kirsti Kvaløy, Mika Kähönen, Timo A. Lakka, Lenore J. Launer, Benjamin Lehne, Cecilia M. Lindgren, Mattias Lorentzon, Robert Luben, Michel Marre, Yuri Milaneschi, Keri L. Monda, Grant W. Montgomery, Marleen H. M. De Moor, Antonella Mulas, Martina Müller-Nurasyid, A. W. Musk, Reija Männikkö, Satu Männistö, Narisu, Matthias Nauck, Jennifer A. Nettleton, Ilja M. Nolte, Albertine J. Oldehinkel, Matthias Olden, Ken K. Ong, Sandosh Padmanabhan, Lavinia Paternoster, Jeremiah Perez, Markus Perola, Annette Peters, Ulrike Peters, Patricia A. Peyser, Inga Prokopenko, Hannu Puolijoki, Olli T. Raitakari, Tuomo Rankinen, Laura J. Rasmussen-Torvik, Rajesh Rawal, Paul M. Ridker, Lynda M. Rose, Igor Rudan, Cinzia Sarti, Mark A. Sarzynski, Kai Savonen, William R. Scott, Serena Sanna, Alan R. Shuldiner, Steve Sidney, Günther Silbernagel, Blair H. Smith, Jennifer A. Smith, Harold Snieder, Alena Stančáková, Barbara Sternfeld, Amy J. Swift, Tuija Tammelin, Sian-Tsung Tan, Barbara Thorand, Dorothée Thuillier, Liesbeth Vandenput, Henrik Vestergaard, Jana V. van Vliet-Ostaptchouk, Marie-Claude Vohl, Uwe Völker, Gérard Waeber, Mark Walker, Sarah Wild, Andrew Wong, Alan F. Wright, M. Carola Zillikens, Niha Zubair, Christopher A. Haiman, Loic Lemarchand, Ulf Gyllensten, Claes Ohlsson, Albert Hofman, Fernando Rivadeneira, André G. Uitterlinden, Louis Pérusse, James F. Wilson, Caroline Hayward, Ozren Polasek, Francesco Cucca, Kristian Hveem, Catharina A. Hartman, Anke Tönjes, Stefania Bandinelli, Lyle J. Palmer, Sharon L. R. Kardia, Rainer Rauramaa, Thorkild I. A. Sørensen, Jaakko Tuomilehto, Veikko Salomaa, Brenda W. J. H. Penninx, Eco J. C. de Geus, Dorret I. Boomsma, Terho Lehtimäki, Massimo Mangino, Markku Laakso, Claude Bouchard, Nicholas G. Martin, Diana Kuh, Yongmei Liu, Allan Linneberg, Winfried März, Konstantin Strauch, Mika Kivimäki, Tamara B. Harris, Vilmundur Gudnason, Henry Völzke, Lu Qi, Marjo-Riitta Järvelin, John C. Chambers, Jaspal S. Kooner, Philippe Froguel, Charles Kooperberg, Peter Vollenweider, Göran Hallmans, Torben Hansen, Oluf Pedersen, Andres Metspalu, Nicholas J. Wareham, Claudia Langenberg, David R. Weir, David J. Porteous, Eric Boerwinkle, Daniel I. Chasman, Gonçalo R. Abecasis, Inês Barroso, Mark I. McCarthy, Timothy M. Frayling, Jeffrey R. O’Connell, Cornelia M. van Duijn, Michael Boehnke, Iris M. Heid, Karen L. Mohlke, David P. Strachan, Caroline S. Fox, Ching-Ti Liu, Joel N. Hirschhorn, Robert J. Klein, Andrew D. Johnson, Ingrid B. Borecki, Paul W. Franks, Kari E. North, L. Adrienne Cupples, Ruth J. F. Loos, Tuomas O. Kilpeläinen

Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 300 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Finland 1 <1%
Unknown 297 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 72 24%
Student > Ph. D. Student 42 14%
Student > Master 34 11%
Professor 24 8%
Professor > Associate Professor 20 7%
Other 60 20%
Unknown 48 16%
Readers by discipline Count As %
Medicine and Dentistry 54 18%
Biochemistry, Genetics and Molecular Biology 49 16%
Agricultural and Biological Sciences 38 13%
Nursing and Health Professions 17 6%
Sports and Recreations 13 4%
Other 55 18%
Unknown 74 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 218. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2019.
All research outputs
#82,383
of 15,942,222 outputs
Outputs from PLoS Genetics
#60
of 7,223 outputs
Outputs of similar age
#2,946
of 268,326 outputs
Outputs of similar age from PLoS Genetics
#3
of 159 outputs
Altmetric has tracked 15,942,222 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,223 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,326 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 159 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.