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Treating inflammation by blocking interleukin-1 in humans

Overview of attention for article published in Seminars in Immunology, November 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

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3 X users
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3 patents
facebook
1 Facebook page

Citations

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445 Dimensions

Readers on

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577 Mendeley
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2 CiteULike
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Title
Treating inflammation by blocking interleukin-1 in humans
Published in
Seminars in Immunology, November 2013
DOI 10.1016/j.smim.2013.10.008
Pubmed ID
Authors

Charles A Dinarello, Jos W M van der Meer

Abstract

IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL-1-mediated inflammation. Although IL-1, either IL-1α or IL-1β, was administered to patients in order to improve bone marrow function or increase host immune responses to cancer, these patients experienced unacceptable toxicity with fever, anorexia, myalgias, arthralgias, fatigue, gastrointestinal upset and sleep disturbances; frank hypotension occurred. Thus it was not unexpected that specific pharmacological blockade of IL-1 activity in inflammatory diseases would be beneficial. Monotherapy blocking IL-1 activity in a broad spectrum of inflammatory syndromes results in a rapid and sustained reduction in disease severity. In common conditions such as heart failure and gout arthritis, IL-1 blockade can be effective therapy. Three IL-1blockers have been approved: the IL-1 receptor antagonist, anakinra, blocks the IL-1 receptor and therefore reduces the activity of IL-1α and IL-1β. A soluble decoy receptor, rilonacept, and a neutralizing monoclonal anti-interleukin-1β antibody, canakinumab, are also approved. A monoclonal antibody directed against the IL-1 receptor and a neutralizing anti-IL-1α are in clinical trials. By specifically blocking IL-1, we have learned a great deal about the role of this cytokine in inflammation but equally important, reducing IL-1 activity has lifted the burden of disease for many patients.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 577 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 3 <1%
United Kingdom 3 <1%
Germany 2 <1%
United States 2 <1%
Brazil 1 <1%
India 1 <1%
Peru 1 <1%
France 1 <1%
Mexico 1 <1%
Other 1 <1%
Unknown 561 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 91 16%
Student > Master 78 14%
Researcher 69 12%
Student > Bachelor 62 11%
Other 35 6%
Other 123 21%
Unknown 119 21%
Readers by discipline Count As %
Medicine and Dentistry 173 30%
Agricultural and Biological Sciences 89 15%
Biochemistry, Genetics and Molecular Biology 59 10%
Immunology and Microbiology 43 7%
Pharmacology, Toxicology and Pharmaceutical Science 17 3%
Other 65 11%
Unknown 131 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2021.
All research outputs
#6,333,243
of 25,374,647 outputs
Outputs from Seminars in Immunology
#328
of 916 outputs
Outputs of similar age
#66,396
of 315,186 outputs
Outputs of similar age from Seminars in Immunology
#11
of 24 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 916 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,186 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.