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Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

Overview of attention for article published in Clinical Cancer Research, February 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
1 news outlet
twitter
2 tweeters
patent
1 patent

Citations

dimensions_citation
203 Dimensions

Readers on

mendeley
171 Mendeley

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Summary News Twitter Patents Dimensions citations
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Title
Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Published in
Clinical Cancer Research, February 2014
DOI 10.1158/1078-0432.ccr-13-1854
Pubmed ID
24323901
Authors

Yasmine Touil, Wassila Igoudjil, Matthieu Corvaisier, Anne-Frédérique Dessein, Jérôme Vandomme, Didier Monté, Laurence Stechly, Nicolas Skrypek, Carole Langlois, Georges Grard, Guillaume Millet, Emmanuelle Leteurtre, Patrick Dumont, Stéphanie Truant, François-René Pruvot, Mohamed Hebbar, Fan, Lee M. Ellis, Pierre Formstecher, Isabelle Van Seuningen, Christian Gespach, Renata Polakowska, Guillemette Huet

Abstract

Metastasis and drug resistance are the major limitations in the survival and management of patients with cancer. This study aimed to identify the mechanisms underlying HT29 colon cancer cell chemoresistance acquired after sequential exposure to 5-fluorouracil (5FU), a classical anticancer drug for treatment of epithelial solid tumors. We examined its clinical relevance in a cohort of patients with colon cancer with liver metastases after 5FU-based neoadjuvant chemotherapy and surgery.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
France 1 <1%
Italy 1 <1%
Canada 1 <1%
Unknown 167 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 21%
Student > Master 31 18%
Researcher 23 13%
Student > Bachelor 21 12%
Student > Doctoral Student 9 5%
Other 22 13%
Unknown 29 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 58 34%
Agricultural and Biological Sciences 34 20%
Medicine and Dentistry 29 17%
Immunology and Microbiology 4 2%
Engineering 3 2%
Other 8 5%
Unknown 35 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2022.
All research outputs
#2,013,137
of 21,423,731 outputs
Outputs from Clinical Cancer Research
#1,633
of 12,197 outputs
Outputs of similar age
#26,633
of 303,866 outputs
Outputs of similar age from Clinical Cancer Research
#22
of 185 outputs
Altmetric has tracked 21,423,731 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,197 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 303,866 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 185 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.

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