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Leukocyte Filtration Lesion Impairs Functional Coagulation in Banked Whole Blood

Overview of attention for article published in Journal of Trauma and Acute Care Surgery, The, April 2017
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Title
Leukocyte Filtration Lesion Impairs Functional Coagulation in Banked Whole Blood
Published in
Journal of Trauma and Acute Care Surgery, The, April 2017
DOI 10.1097/ta.0000000000001535
Pubmed ID
Authors

Anaar Siletz, Sigrid Burruss, Terry Gruber, Alyssa Ziman, Victor Marder, Henry Magill Cryer

Abstract

Whole blood (WB) transfusion is a promising alternative to component therapy in hemostatic resuscitation. Use of banked WB requires filtration of white blood cells (leukoreduction) and an established shelf life during which WB retains coagulant capacities. The goal of this study was to define the time course of coagulation stability in leukoreduced compared to unfiltered WB under standard refrigeration conditions. Twelve WB units were donated by healthy volunteers after routine screening. Five units underwent standard leukocyte filtration and five did not. Two units were aliquoted into filtered and unfiltered samples, with platelets added to each sample on Day 14. Units were stored at 4°C and sampled on days 0, 1, 2, 3, 4, 5, 6, 7, 10, 14, 21, 28, and 35 for immediate thromboelastogram (TEG) analysis, and centrifuged and stored at -80°C for later Calibrated Automated Thrombogram (CAT) and coagulation factor assays. K-dependent factors and fibrinogen were low normal, decreased slightly over 35 days, and were similar between unfiltered and filtered units. Labile factors were better preserved in filtered units, although unfiltered units did not show impaired coagulation over 35 days. Filtered blood had delayed clot initiation on days 0, 1, and 2 as measured by TEG R (p<0.021); slower clot progression (TEG α-angle) on days 0, 1, 2, 3, 4, 5, and 6 (p<0.023); weaker final clot (TEG MA) on all days (p<0.0001). Thrombin generation was delayed on day 28 (p=0.046) and decreased on days 10, 21, 28, and 35 (p<0.034). Addition of platelets to filtered WB rescued TEG MA. Filtered WB had decreased functional clotting capacity and thrombin generation and may not be suitable for hemostatic resuscitation as the sole blood product. Laboratory study.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 25%
Other 1 25%
Student > Ph. D. Student 1 25%
Researcher 1 25%
Readers by discipline Count As %
Medicine and Dentistry 2 50%
Nursing and Health Professions 1 25%
Biochemistry, Genetics and Molecular Biology 1 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2017.
All research outputs
#9,426,982
of 11,794,580 outputs
Outputs from Journal of Trauma and Acute Care Surgery, The
#2,403
of 3,008 outputs
Outputs of similar age
#190,493
of 266,300 outputs
Outputs of similar age from Journal of Trauma and Acute Care Surgery, The
#141
of 207 outputs
Altmetric has tracked 11,794,580 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,008 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,300 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 207 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.