Title |
Safety and efficacy of short-term oral immunotherapy with Cry j 1-galactomannan conjugate for Japanese cedar pollinosis: a randomized controlled trial
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Published in |
Scientific Reports, April 2017
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DOI | 10.1038/srep46142 |
Pubmed ID | |
Authors |
Daisuke Murakami, Motohiro Sawatsubashi, Hirofumi Omori, Akira Saito, Akio Kato, Shizuo Komune, Takashi Nakagawa |
Abstract |
Current allergen-specific immunotherapy (AIT) for pollinosis requires long-term treatment with potentially severe side effects. Therefore, development of an AIT that is safe and more convenient with a shorter regimen is needed. This prospective, double-blind, placebo-controlled trial randomized 55 participants with Japanese cedar pollinosis (JCP) to active or placebo groups to test the safety and efficacy of short-term oral immunotherapy (OIT) with Cry j 1-galactomannan conjugate for JCP. Mean symptom-medication score as the primary outcome in the active group improved 27.8% relative to the placebo group during the entire pollen season. As the secondary outcomes, mean medication score in active group improved significantly, by 56.2%, compared with placebo during the entire pollen season. Mean total symptom score was similar between active and placebo groups during the entire pollen season. There were no severe treatment-emergent adverse events in the active and placebo groups. Therefore short-term OIT with Cry j 1-galactomannan conjugate is safe, and effective for reducing the amount of medication use for JCP. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 18% |
Student > Bachelor | 3 | 18% |
Student > Ph. D. Student | 2 | 12% |
Other | 1 | 6% |
Student > Doctoral Student | 1 | 6% |
Other | 1 | 6% |
Unknown | 6 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 29% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 12% |
Agricultural and Biological Sciences | 1 | 6% |
Immunology and Microbiology | 1 | 6% |
Engineering | 1 | 6% |
Other | 0 | 0% |
Unknown | 7 | 41% |