| Chapter title |
Development and Functional Differentiation of Tissue-Resident Versus Monocyte-Derived Macrophages in Inflammatory Reactions
|
|---|---|
| Chapter number | 2 |
| Book title |
Macrophages
|
| Published in |
Results and problems in cell differentiation, April 2017
|
| DOI | 10.1007/978-3-319-54090-0_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-954089-4, 978-3-31-954090-0
|
| Authors |
Paola Italiani, Diana Boraschi |
| Editors |
Malgorzata Kloc |
| Abstract |
Mononuclear phagocytes are key cells in tissue integrity and defense. Tissue-resident macrophages are abundantly present in all tissues of the body and have a complex role in ensuring tissue functions and homeostatic balance. Circulating blood monocytes can enter tissue both in steady-state conditions, for helping in replenishing the tissue-resident macrophage pool and, in particular, for acting as potent effector cells during inflammatory events such as infections, traumas, and diseases. The heterogeneity of monocytes and macrophages depends on their ontogeny, their tissue location, and their functional programming, with both monocytes and macrophages able to exert distinct or similar functions depending on the tissue-specific and stimulus-specific microenvironment. In this short review, we will review the current hypotheses on tissue-resident macrophage ontogeny and functions, as compared to blood-derived monocytes, with a particular focus on inflammatory conditions. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 22% |
| Student > Bachelor | 12 | 18% |
| Student > Master | 9 | 13% |
| Researcher | 6 | 9% |
| Other | 5 | 7% |
| Other | 5 | 7% |
| Unknown | 15 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 13 | 19% |
| Biochemistry, Genetics and Molecular Biology | 12 | 18% |
| Medicine and Dentistry | 9 | 13% |
| Agricultural and Biological Sciences | 9 | 13% |
| Environmental Science | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 18 | 27% |