| Chapter title |
Macrophages and RhoA Pathway in Transplanted Organs
|
|---|---|
| Chapter number | 15 |
| Book title |
Macrophages
|
| Published in |
Results and problems in cell differentiation, April 2017
|
| DOI | 10.1007/978-3-319-54090-0_15 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-954089-4, 978-3-31-954090-0
|
| Authors |
Yianzhu Liu, Jacek Z. Kubiak, Xian C. Li, Rafik M. Ghobrial, Malgorzata Kloc |
| Editors |
Malgorzata Kloc |
| Abstract |
RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also pivotal for proper functioning of immune cells including macrophages. By controlling actin cytoskeleton organization, RhoA pathway modulates macrophage's polarity and basic functions: phagocytosis, migration, and extracellular matrix degradation. Numerous studies indicate that macrophages are very important effectors contributing to acute and chronic rejection of transplanted organs. In this review we discuss the role of RhoA pathway in governance of macrophage's functions in terms of transplanted organs. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 2 | 25% |
| Professor | 1 | 13% |
| Student > Ph. D. Student | 1 | 13% |
| Student > Master | 1 | 13% |
| Researcher | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 2 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 25% |
| Immunology and Microbiology | 2 | 25% |
| Nursing and Health Professions | 1 | 13% |
| Medicine and Dentistry | 1 | 13% |
| Unknown | 2 | 25% |