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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic CJD with a novel E200G mutation in the prion protein gene and comparison with E200K mutation cases
|
|---|---|
| Published in |
Acta Neuropathologica Communications, December 2013
|
| DOI | 10.1186/2051-5960-1-80 |
| Pubmed ID | |
| Authors |
Mee-Ohk Kim, Ignazio Cali, Abby Oehler, Jamie C Fong, Katherine Wong, Tricia See, Jonathan S Katz, Pierluigi Gambetti, Brianne M Bettcher, Stephen J DeArmond, Michael D Geschwind |
| Abstract |
A novel point mutation resulting in a glutamate-to-glycine substitution in PRNP at codon 200, E200G with codon 129 MV polymorphism (cis valine) and type 2 PrPSc was identified in a patient with a prolonged disease course leading to pathology-proven Jakob-Creutzfeldt disease. Despite the same codon as the most common genetic form of human PRNP mutation, E200K, this novel mutation (E200G) presented with a different clinical and pathological phenotype, including prolonged duration, large vacuoles, no vacuolation in the hippocampus, severe neuronal loss in the thalamus, mild cerebellar involvement, and abundant punctate linear and curvilinear deposition of PrPSc in synaptic boutons and axonal terminals along the dendrites. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 4% |
| Unknown | 25 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 23% |
| Researcher | 5 | 19% |
| Student > Doctoral Student | 3 | 12% |
| Other | 3 | 12% |
| Student > Postgraduate | 2 | 8% |
| Other | 4 | 15% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 23% |
| Biochemistry, Genetics and Molecular Biology | 5 | 19% |
| Neuroscience | 5 | 19% |
| Medicine and Dentistry | 2 | 8% |
| Immunology and Microbiology | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 4 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2017.
All research outputs
#3,772,949
of 22,736,112 outputs
Outputs from Acta Neuropathologica Communications
#747
of 1,368 outputs
Outputs of similar age
#45,300
of 307,106 outputs
Outputs of similar age from Acta Neuropathologica Communications
#7
of 28 outputs
Altmetric has tracked 22,736,112 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,368 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,106 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.