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Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers

Overview of attention for article published in BMC Microbiology, April 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

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1 news outlet
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Title
Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers
Published in
BMC Microbiology, April 2017
DOI 10.1186/s12866-017-0997-3
Pubmed ID
Authors

Anne-Merethe Hanssen, Bert Kindlund, Niels Christian Stenklev, Anne-Sofie Furberg, Silje Fismen, Renate Slind Olsen, Mona Johannessen, Johanna Ulrica Ericson Sollid

Abstract

Colonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is the anterior nares. More than 60% of the S. aureus in the nose are found in vestibulum nasi. Our aim was to describe the localization of S. aureus in nasal tissue from healthy carriers. Punch skin biopsies were taken from vestibulum nasi from healthy volunteers (S. aureus carriers and non-/intermittent carriers, n = 39) attending the population-based Tromsø 6 study. The tissue samples were processed as frozen sections before immunostaining with a specific S. aureus antibody, and finally evaluated by a confocal laser-scanning microscope. Our results suggest that S. aureus colonize both the upper and lower layers of the epidermis within the nasal epithelium of healthy individuals. The number of S. aureus in epidermis was surprisingly low. Intracellular localization of S. aureus in nasal tissue from healthy individuals was also detected. Knowledge of the exact localization of S. aureus in nasal tissue is important for the understanding of the host responses against S. aureus. Our results may have consequences for the eradication strategy of S. aureus in carriers, and further work can provide us with tools for targeted prevention of S. aureus colonisation and infection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 108 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 20 19%
Student > Ph. D. Student 13 12%
Student > Master 12 11%
Researcher 10 9%
Student > Postgraduate 4 4%
Other 12 11%
Unknown 37 34%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 16%
Immunology and Microbiology 15 14%
Agricultural and Biological Sciences 14 13%
Medicine and Dentistry 8 7%
Veterinary Science and Veterinary Medicine 4 4%
Other 8 7%
Unknown 42 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2017.
All research outputs
#3,223,783
of 22,968,808 outputs
Outputs from BMC Microbiology
#293
of 3,206 outputs
Outputs of similar age
#61,812
of 309,584 outputs
Outputs of similar age from BMC Microbiology
#9
of 62 outputs
Altmetric has tracked 22,968,808 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,206 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,584 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.