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Clinical, diagnostic and immunological characteristics of patients with possible neuroborreliosis without intrathecal Ig-synthesis against Borrelia antigen in the cerebrospinal fluid.

Overview of attention for article published in Neurology International, June 2011
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Title
Clinical, diagnostic and immunological characteristics of patients with possible neuroborreliosis without intrathecal Ig-synthesis against Borrelia antigen in the cerebrospinal fluid.
Published in
Neurology International, June 2011
DOI 10.4081/ni.2011.e2
Pubmed ID
Authors

Vrethem M, Widhe M, Ernerudh J, Garpmo U, Forsberg P

Abstract

The diagnosis of neuroborreliosis is not always straightforward. Intrathecal immunoglobulin (Ig) synthesis against Borrelia antigen may not be detected, at least early in the disease course. Also other neurological and infectious diagnoses have to be considered. We have studied patients with clinical possible neuroborreliosis without intrathecal Ig synthesis against Borrelia antigen in the cerebrospinal fluid (CSF) (n=17). Diagnosis was based on typical clinical history and at least one of the following findings; mononuclear leucocytosis in the CSF (n=4); typical erythema migrans >5 cm in diameter in relation to debut of symptoms (n=8); prompt clinical response to antibiotic teratment (n=14). Also other possible diagnoses had to be excluded. Seventeen patients first investigated because of suspected neuroborreliosis but later confirmed with other diagnoses were used as controls. All patients had a lumbar puncture. Borrelia specific IFN-γ and IL-4 secretion was investigated in peripheral blood (PBL) and CSF with an ELISPOT assay. Polymerase chain reaction (PCR) was used to reveal any Borrelia antigen in the CSF. Six of 17 patients with possible neuroborreliosis showed high IFN-γ secretion in peripheral blood, otherwise we found no statistically significant differences between the groups. PCR did not reveal any Borrelia antigen in CSF. The diagnosis and treatment of possible but not confirmed neuroborreliosis is a clinical challenge. The clinical response to treatment may be the best option in these cases.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
United States 1 5%
Unknown 17 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 26%
Other 4 21%
Professor > Associate Professor 4 21%
Librarian 2 11%
Student > Master 1 5%
Other 3 16%
Readers by discipline Count As %
Medicine and Dentistry 9 47%
Agricultural and Biological Sciences 4 21%
Philosophy 1 5%
Unspecified 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 3 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2011.
All research outputs
#4,643,237
of 5,569,395 outputs
Outputs from Neurology International
#30
of 37 outputs
Outputs of similar age
#53,035
of 61,799 outputs
Outputs of similar age from Neurology International
#1
of 2 outputs
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