Title |
Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer's disease
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Published in |
BMC Neuroscience, December 2006
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DOI | 10.1186/1471-2202-7-78 |
Pubmed ID | |
Authors |
Feiqi Zhu, Caiyun Qian |
Abstract |
Berberine is the major alkaloidal component of Rhizoma coptidis, and has multiple pharmacological effects including inhibiting acetylcholinesterase, reducing cholesterol and glucose, lowering mortality in patients with chronic congestive heart failure and anti-inflammation etc. Thus berberine is a promising drug for diabetes, hyperlipemia, coronary artery disease and ischemic stroke etc. The present study was carried out to investigate the effect of berberine chloride on the spatial memory, inflammation factors interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) expression in the rat model of Alzheimer's disease (AD) which was established by injecting Abeta (1-40) (5 microgram) into the rats hippocampuses bilaterally. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Iran, Islamic Republic of | 1 | 1% |
Malaysia | 1 | 1% |
Poland | 1 | 1% |
Unknown | 94 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 13% |
Student > Master | 12 | 12% |
Student > Bachelor | 11 | 11% |
Researcher | 9 | 9% |
Professor > Associate Professor | 9 | 9% |
Other | 19 | 20% |
Unknown | 24 | 25% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 14 | 14% |
Medicine and Dentistry | 14 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 12% |
Chemistry | 6 | 6% |
Biochemistry, Genetics and Molecular Biology | 5 | 5% |
Other | 12 | 12% |
Unknown | 34 | 35% |