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Effect of bee venom on IL-6, COX-2 and VEGF levels in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate

Overview of attention for article published in Journal of Venomous Animals and Toxins including Tropical Diseases, January 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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1 tweeter
facebook
4 Facebook pages

Citations

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13 Dimensions

Readers on

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32 Mendeley
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Title
Effect of bee venom on IL-6, COX-2 and VEGF levels in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate
Published in
Journal of Venomous Animals and Toxins including Tropical Diseases, January 2013
DOI 10.1186/1678-9199-19-32
Pubmed ID
Authors

Latifeh Karimzadeh, Mohammad Nabiuni, Homa Kouchesfehani, Hamed Adham, Amir Bagheri, Azar Sheikholeslami

Abstract

Polycystic ovarian syndrome (PCOS) is a low-grade inflammatory disease characterized by hyperandrogenemia, hirsutism, chronic anovulation and vascular disorder. Interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are triggered by inflammatory stimuli and lead to angiogenesis and pathogenesis of the ovary. Honeybee venom (HBV) contains an array of biologically active components possessing various pharmaceutical properties. This study was designed to assess the possibility of HBV application as an anti-inflammatory therapeutic agent to suppress levels of the main inflammatory mediators IL-6, COX-2 and VEGF.To induce PCOS, 1 mg of estradiol valerate (EV) per 100 g of body weight was subcutaneously (SC) injected into eight-week-old rats. After 60 days, 0.5 mg/kg of HBV was administered Intraperitoneal (IP) for 14 consecutive days, and the results of PCOS treatment were investigated. Rats were then anesthetized with CO2, and the ovaries were surgically removed. Serum IL-6 was detected by the ELISA kit. Immunoexpression of COX-2 and VEGF were examined in three groups: EV-induced PCOS, HBV-treated PCOS and control animals.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 3%
Yemen 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 25%
Student > Ph. D. Student 6 19%
Researcher 3 9%
Professor 2 6%
Student > Doctoral Student 2 6%
Other 4 13%
Unknown 7 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 28%
Medicine and Dentistry 6 19%
Biochemistry, Genetics and Molecular Biology 4 13%
Chemistry 2 6%
Immunology and Microbiology 1 3%
Other 3 9%
Unknown 7 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2013.
All research outputs
#2,146,638
of 4,655,094 outputs
Outputs from Journal of Venomous Animals and Toxins including Tropical Diseases
#1
of 1 outputs
Outputs of similar age
#50,026
of 125,215 outputs
Outputs of similar age from Journal of Venomous Animals and Toxins including Tropical Diseases
#3
of 7 outputs
Altmetric has tracked 4,655,094 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 1 research outputs from this source. They receive a mean Attention Score of 0.0. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 125,215 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.