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Long-term outcomes of liver transplantation in patients with hepatitis C infection are not affected by HCV positivity of a donor

Overview of attention for article published in BMC Gastroenterology, November 2016
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Title
Long-term outcomes of liver transplantation in patients with hepatitis C infection are not affected by HCV positivity of a donor
Published in
BMC Gastroenterology, November 2016
DOI 10.1186/s12876-016-0551-z
Pubmed ID
Authors

Maria Stepanova, Mehmet Sayiner, Leyla de Avila, Zahra Younoszai, Andrei Racila, Zobair M. Younossi

Abstract

The use of HCV-positive livers for HCV-positive recipients is becoming more common. Our aim is to evaluate long-term outcomes in liver transplant recipients transplanted with HCV antibody-positive organs. From the Scientific Registry of Transplant Recipients (1995-2013), we selected all adult liver transplant recipients with HCV, and cross-sectionally compared long-term graft loss and mortality rates between those who were transplanted from HCV antibody-positive (HCV+) vs. HCV antibody-negative donors. We included 33,668 HCV+ liver transplant recipients (54.0 ± 7.7 years old, 74.1% male, 71.0% white, 23.6% with liver malignancy). Of those, 5.7% (N = 1930) were transplanted from HCV+ donors; the proportion gradually increased from 2.9% in 1995 to 9.4% in 2013. Patients who were transplanted from HCV+ positive donors were more likely to be discharged alive after transplantation (95.4% vs. 93.9%, p = 0.006), but this difference was completely accounted for by a greater proportion of HCV+ donors in more recent study years (p = 0.10 after adjustment for the transplant year). After transplantation, both mortality in HCV patients transplanted from HCV+ donors (12.5% in 1 year, 24.2% in 3 years, 33.0% in 5 years) and the graft loss rate (2.2% in 1 year, 4.8% in 3 years, 7.5% in 5 years) were similar to those in HCV patients transplanted from HCV-negative donors (all p > 0.05). Over the past two decades, the use of HCV+ organs for liver transplantation has tripled. Despite this, the long-term outcomes of HCV+ liver transplant recipients transplanted from HCV+ donors were not different from those who were transplanted with HCV-negative organs.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Other 8 17%
Unspecified 6 13%
Student > Doctoral Student 6 13%
Student > Bachelor 4 9%
Researcher 4 9%
Other 13 28%
Unknown 5 11%
Readers by discipline Count As %
Medicine and Dentistry 23 50%
Unspecified 6 13%
Nursing and Health Professions 3 7%
Immunology and Microbiology 2 4%
Neuroscience 2 4%
Other 3 7%
Unknown 7 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2017.
All research outputs
#18,546,002
of 22,968,808 outputs
Outputs from BMC Gastroenterology
#1,134
of 1,761 outputs
Outputs of similar age
#232,873
of 306,961 outputs
Outputs of similar age from BMC Gastroenterology
#10
of 14 outputs
Altmetric has tracked 22,968,808 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,761 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,961 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.