Title |
A flexible statistical model for alignment of label-free proteomics data - incorporating ion mobility and product ion information
|
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Published in |
BMC Bioinformatics, December 2013
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DOI | 10.1186/1471-2105-14-364 |
Pubmed ID | |
Authors |
Ashlee M Benjamin, J Will Thompson, Erik J Soderblom, Scott J Geromanos, Ricardo Henao, Virginia B Kraus, M Arthur Moseley, Joseph E Lucas |
Abstract |
The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, specifically label-free LC-MS/MS, allows rapid measurement of thousands of proteins, enabling large-scale studies of various biological systems. Prior to analyzing these information-rich datasets, raw data must undergo several computational processing steps. We present a method to address one of the essential steps in proteomics data processing--the matching of peptide measurements across samples. |
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