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Gender-Specific Association between Angiotensin II Type 2 Receptor −1332 A/G Gene Polymorphism and Advanced Carotid Atherosclerosis

Overview of attention for article published in Journal of Stroke & Cerebrovascular Diseases, July 2016
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2 tweeters

Citations

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4 Dimensions

Readers on

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20 Mendeley
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Title
Gender-Specific Association between Angiotensin II Type 2 Receptor −1332 A/G Gene Polymorphism and Advanced Carotid Atherosclerosis
Published in
Journal of Stroke & Cerebrovascular Diseases, July 2016
DOI 10.1016/j.jstrokecerebrovasdis.2016.03.011
Pubmed ID
Authors

Ana Kolaković, Aleksandra Stanković, Tamara Djurić, Maja Živković, Igor Končar, Lazar Davidović, Djordje Radak, Dragan Alavantić

Abstract

The angiotensin II type 2 receptor (AT2R) -1332 A/G polymorphism has been denoted as functional and associated with certain cardiovascular disease phenotypes. However, there are no studies considering the association of this gene polymorphism with carotid atherosclerosis (CA) and cerebrovascular events. Therefore, the aim of our study was to investigate a possible association of the AT2R -1332 A/G polymorphism with the occurrence of carotid plaques (CPs) and history of cerebrovascular insult (CVI) in advanced CA. The study group included 381 controls and 509 patients with CA consecutively admitted for endarterectomy. Genotyping was determined by polymerase chain reaction-restriction fragment length polymorphism method. The association was analyzed separately for males and females because the AT2R gene is located on the X chromosome. The AT2R -1332 GG genotype was associated with the advanced CA in the female study group (recessive model of inheritance, AA+AG versus GG; adjusted odds ratio [OR] = 2.25; 95% confidence interval [CI] 1.17-4.33; P = .01). In the male subgroup of patients with CA, the significant overrepresentation of G/- hemizygote was detected in patients with CVI compared to male patients without this event (crude OR = 2.05, 95% CI 1.20-3.50, P = .008). This study suggests a gender-specific association between the AT2R -1332 A/G polymorphism and the occurrence of CP and the history of CVI in advanced CA, but further replication studies are needed.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 20%
Student > Bachelor 3 15%
Student > Master 2 10%
Professor 2 10%
Student > Ph. D. Student 2 10%
Other 4 20%
Unknown 3 15%
Readers by discipline Count As %
Medicine and Dentistry 4 20%
Biochemistry, Genetics and Molecular Biology 4 20%
Agricultural and Biological Sciences 2 10%
Nursing and Health Professions 1 5%
Business, Management and Accounting 1 5%
Other 3 15%
Unknown 5 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2017.
All research outputs
#7,690,371
of 12,357,867 outputs
Outputs from Journal of Stroke & Cerebrovascular Diseases
#544
of 1,181 outputs
Outputs of similar age
#148,693
of 267,567 outputs
Outputs of similar age from Journal of Stroke & Cerebrovascular Diseases
#18
of 45 outputs
Altmetric has tracked 12,357,867 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,181 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,567 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.