↓ Skip to main content

TNF-α and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation.

Overview of attention for article published in Annali dell'Istituto Superiore di Sanità, October 2015
Altmetric Badge

About this Attention Score

  • Among the highest-scoring outputs from this source (#45 of 129)
  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
22 Dimensions

Readers on

mendeley
1 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
TNF-α and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation.
Published in
Annali dell'Istituto Superiore di Sanità, October 2015
DOI 10.4415/ann_15_04_21
Pubmed ID
Authors

Carito, Valentina, Ciafrh, Stefania, Tarani, Luigi, Ceccanti, Mauro, Natella, Fausta, Iannitelli, Angela, Tirassa, Paola, Chaldakov, George N., Ceccanti, Marco, Boccardo, Chiara, Fiore, Marco

Abstract

Polyphenols from olive are known to possess antioxidant and anti-inflammatory properties. The aim of this study was to study whether or not 10 consecutive days i.p. administration of a blend of olive (Olea europaea L.) polyphenols (10 mg/kg) containing mostly hydroxytyrosol could have an effect on cytokines playing important roles in inflammatory processes as TNF-α and IL-10. Inflammation was induced in the mouse paw by 2 carrageenan injections (50 µl vol, 5 mg/kg each). TNF-α and IL-10 were measured by enzyme-linked immunosorbent assay. Carrageenan decreased IL-10 in the paws, however, this reduction appeared to be less evident in mice treated with carrageenan but administered with polyphenols. As for TNF-α, our findings did not reveal differences between groups but an increase in the polyphenol and carrageenan group if compared to the carrageenan only group. As for antioxidant polyphenols' properties, no differences between groups in the serum glutathione were found. Altogether, this investigation shows that olive polyphenols in the mouse may modulate the levels of cytokines having a role in the process of inflammation as TNF-α and IL-10.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 900%
Student > Postgraduate 3 300%
Student > Ph. D. Student 3 300%
Professor 2 200%
Student > Bachelor 2 200%
Other 8 800%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 700%
Medicine and Dentistry 6 600%
Agricultural and Biological Sciences 4 400%
Neuroscience 3 300%
Chemistry 2 200%
Other 3 300%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2017.
All research outputs
#5,513,199
of 9,768,421 outputs
Outputs from Annali dell'Istituto Superiore di Sanità
#45
of 129 outputs
Outputs of similar age
#147,101
of 263,139 outputs
Outputs of similar age from Annali dell'Istituto Superiore di Sanità
#1
of 4 outputs
Altmetric has tracked 9,768,421 research outputs across all sources so far. This one is in the 26th percentile – i.e., 26% of other outputs scored the same or lower than it.
So far Altmetric has tracked 129 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,139 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them