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Glutathione and its antiaging and antimelanogenic effects

Overview of attention for article published in Clinical, Cosmetic and Investigational Dermatology, April 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 900)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
16 news outlets
blogs
1 blog
twitter
188 X users
patent
2 patents
facebook
4 Facebook pages
googleplus
2 Google+ users
video
4 YouTube creators

Citations

dimensions_citation
66 Dimensions

Readers on

mendeley
184 Mendeley
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Title
Glutathione and its antiaging and antimelanogenic effects
Published in
Clinical, Cosmetic and Investigational Dermatology, April 2017
DOI 10.2147/ccid.s128339
Pubmed ID
Authors

Sinee Weschawalit, Siriwan Thongthip, Phanupong Phutrakool, Pravit Asawanonda

Abstract

Previous studies showed that supplementation of reduced form of glutathione (GSH, 500 mg/d) has a skin-lightening efficacy in humans. This study was designed to evaluate the influences of both GSH and oxidized form (GSSG), at doses lower than 500 mg/d, on improving skin properties. A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted. Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks. At each visit at baseline and for 12 weeks, skin features including melanin index, wrinkles, and other relevant biophysical properties were measured. Blood samples were collected for safety monitoring. In generalized estimating equation analyses, melanin index and ultraviolet spots of all sites including face and arm when given GSH and GSSG tended to be lower than placebo. At some sites evaluated, subjects who received GSH showed a significant reduction in wrinkles compared with those taking placebo. A tendency toward increased skin elasticity was observed in GSH and GSSG compared with placebo. There were no serious adverse effects throughout the study. We showed that oral glutathione, 250 mg/d, in both reduced and oxidized forms effectively influences skin properties. Overall, glutathione in both forms are well tolerated.

X Demographics

X Demographics

The data shown below were collected from the profiles of 188 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 184 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 22 12%
Student > Master 20 11%
Researcher 12 7%
Student > Ph. D. Student 9 5%
Other 8 4%
Other 22 12%
Unknown 91 49%
Readers by discipline Count As %
Medicine and Dentistry 25 14%
Biochemistry, Genetics and Molecular Biology 20 11%
Pharmacology, Toxicology and Pharmaceutical Science 17 9%
Agricultural and Biological Sciences 8 4%
Nursing and Health Professions 7 4%
Other 14 8%
Unknown 93 51%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 290. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2023.
All research outputs
#122,383
of 25,584,565 outputs
Outputs from Clinical, Cosmetic and Investigational Dermatology
#20
of 900 outputs
Outputs of similar age
#2,761
of 324,452 outputs
Outputs of similar age from Clinical, Cosmetic and Investigational Dermatology
#1
of 9 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 900 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,452 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them