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Glutathione and its antiaging and antimelanogenic effects

Overview of attention for article published in Clinical, Cosmetic and Investigational Dermatology, April 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 359)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
10 news outlets
blogs
1 blog
twitter
197 tweeters
facebook
3 Facebook pages
googleplus
2 Google+ users
video
4 video uploaders

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
38 Mendeley
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Title
Glutathione and its antiaging and antimelanogenic effects
Published in
Clinical, Cosmetic and Investigational Dermatology, April 2017
DOI 10.2147/ccid.s128339
Pubmed ID
Authors

Sinee Weschawalit, Siriwan Thongthip, Phanupong Phutrakool, Pravit Asawanonda

Abstract

Previous studies showed that supplementation of reduced form of glutathione (GSH, 500 mg/d) has a skin-lightening efficacy in humans. This study was designed to evaluate the influences of both GSH and oxidized form (GSSG), at doses lower than 500 mg/d, on improving skin properties. A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted. Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks. At each visit at baseline and for 12 weeks, skin features including melanin index, wrinkles, and other relevant biophysical properties were measured. Blood samples were collected for safety monitoring. In generalized estimating equation analyses, melanin index and ultraviolet spots of all sites including face and arm when given GSH and GSSG tended to be lower than placebo. At some sites evaluated, subjects who received GSH showed a significant reduction in wrinkles compared with those taking placebo. A tendency toward increased skin elasticity was observed in GSH and GSSG compared with placebo. There were no serious adverse effects throughout the study. We showed that oral glutathione, 250 mg/d, in both reduced and oxidized forms effectively influences skin properties. Overall, glutathione in both forms are well tolerated.

Twitter Demographics

The data shown below were collected from the profiles of 197 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Student > Master 6 16%
Student > Doctoral Student 4 11%
Student > Bachelor 4 11%
Lecturer 3 8%
Other 6 16%
Unknown 8 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 29%
Medicine and Dentistry 8 21%
Agricultural and Biological Sciences 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 8%
Psychology 1 3%
Other 2 5%
Unknown 10 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 253. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2019.
All research outputs
#51,583
of 13,985,632 outputs
Outputs from Clinical, Cosmetic and Investigational Dermatology
#4
of 359 outputs
Outputs of similar age
#2,328
of 264,444 outputs
Outputs of similar age from Clinical, Cosmetic and Investigational Dermatology
#1
of 10 outputs
Altmetric has tracked 13,985,632 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 359 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,444 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them