Title |
Detecting cellular reprogramming determinants by differential stability analysis of gene regulatory networks
|
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Published in |
BMC Systems Biology, December 2013
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DOI | 10.1186/1752-0509-7-140 |
Pubmed ID | |
Authors |
Isaac Crespo, Thanneer M Perumal, Wiktor Jurkowski, Antonio del Sol |
Abstract |
Cellular differentiation and reprogramming are processes that are carefully orchestrated by the activation and repression of specific sets of genes. An increasing amount of experimental results show that despite the large number of genes participating in transcriptional programs of cellular phenotypes, only few key genes, which are coined here as reprogramming determinants, are required to be directly perturbed in order to induce cellular reprogramming. However, identification of reprogramming determinants still remains a combinatorial problem, and the state-of-art methods addressing this issue rests on exhaustive experimentation or prior knowledge to narrow down the list of candidates. |
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Spain | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Luxembourg | 3 | 4% |
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Researcher | 18 | 25% |
Student > Master | 8 | 11% |
Student > Bachelor | 6 | 8% |
Other | 4 | 6% |
Other | 9 | 13% |
Unknown | 6 | 8% |
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Computer Science | 7 | 10% |
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Unspecified | 2 | 3% |
Other | 7 | 10% |
Unknown | 6 | 8% |