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Tau, APP, NCT and BACE1 in lymphocytes through cognitively normal ageing and neuropathology

Overview of attention for article published in Anais da Academia Brasileira de Ciências, January 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (76th percentile)

Mentioned by

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3 tweeters
patent
1 patent

Citations

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10 Dimensions

Readers on

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29 Mendeley
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Title
Tau, APP, NCT and BACE1 in lymphocytes through cognitively normal ageing and neuropathology
Published in
Anais da Academia Brasileira de Ciências, January 2013
DOI 10.1590/0001-376520130013
Pubmed ID
Authors

MARISOL HERRERA-RIVERO, ABRAHAM SOTO-CID, MARIA E. HERNaNDEZ, GONZALO E. ARANDA-ABREU

Abstract

Although Alzheimer's disease is a brain disorder, a number of peripheral alterations have been found in these patients; however, little is known about how the key genes involved in the pathophysiology express in peripheral cells such as lymphocytes during normal compared to neuropathological ageing. We analysed the expression of tau, of the amyloid precursor protein, of nicastrin and of the β-site APP cleaving enzyme genes by RT-PCR in lymphocytes from a small group of late-onset Alzheimer's disease patients, from aged patients suffering from neuropsychological conditions different from Alzheimer's and from cognitively healthy subjects divided in four groups by age. We also investigated correlations between gene expression and levels of blood pressure, glucose, total cholesterol and triglycerides as risk factors for Alzheimer's. Results show no tau expression in lymphocytes, a lack of detection of nicastrin expression in Alzheimer's patients and correlations between the medical conditions studied and gene expression in lymphocytes. We believe nicastrin gene expression in lymphocytes should be considered of interest for further analyses in a wider population to investigate whether it might represent a potential biomarker to differentiate Alzheimer's from other neuropsychological disorders.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Netherlands 1 3%
Unknown 27 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 21%
Researcher 5 17%
Professor 2 7%
Other 2 7%
Student > Master 2 7%
Other 4 14%
Unknown 8 28%
Readers by discipline Count As %
Neuroscience 6 21%
Biochemistry, Genetics and Molecular Biology 3 10%
Medicine and Dentistry 3 10%
Agricultural and Biological Sciences 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 4 14%
Unknown 10 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2022.
All research outputs
#5,457,226
of 20,678,629 outputs
Outputs from Anais da Academia Brasileira de Ciências
#54
of 262 outputs
Outputs of similar age
#70,604
of 297,991 outputs
Outputs of similar age from Anais da Academia Brasileira de Ciências
#1
of 1 outputs
Altmetric has tracked 20,678,629 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 262 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,991 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them