Title |
S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication by NK cells
|
---|---|
Published in |
Retrovirology, October 2013
|
DOI | 10.1186/1742-4690-10-122 |
Pubmed ID | |
Authors |
Vincent Arnold, Jean-Saville Cummings, Uriel Y Moreno-Nieves, Céline Didier, Adrien Gilbert, Françoise Barré-Sinoussi, Daniel Scott-Algara |
Abstract |
The reportedly broad expression of CD85j across different immune cell types suggests an importance for this molecule in the human immune system. Previous reports have shown that this receptor interacts with several HLA class-I molecules, as well as with some viral proteins. We have demonstrated that the subset of CD85j + Natural Killer (NK) cells efficiently controls human immunodeficiency virus type 1 (HIV-1) replication in monocyte-derived dendritic cells (MDDC) in vitro and this led us to hypothesize that the CD85j + NK cell-mediated anti-HIV activity in MDDC is specifically dependent on the interaction between the CD85j receptor and unknown non-HLA class-I ligand(s). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Montenegro | 1 | 2% |
United Kingdom | 1 | 2% |
Germany | 1 | 2% |
Unknown | 54 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 16% |
Researcher | 8 | 14% |
Professor | 7 | 12% |
Student > Doctoral Student | 6 | 11% |
Student > Bachelor | 5 | 9% |
Other | 7 | 12% |
Unknown | 15 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 21% |
Immunology and Microbiology | 12 | 21% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Medicine and Dentistry | 4 | 7% |
Computer Science | 1 | 2% |
Other | 3 | 5% |
Unknown | 16 | 28% |