Chapter title |
Assaying Spontaneous Network Activity and Cellular Viability Using Multi-well Microelectrode Arrays
|
---|---|
Chapter number | 13 |
Book title |
Cell Viability Assays
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6960-9_13 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6959-3, 978-1-4939-6960-9
|
Authors |
Jasmine P. Brown, Brittany S. Lynch, Itaevia M. Curry-Chisolm, Timothy J. Shafer, Jenna D. Strickland |
Editors |
Daniel F. Gilbert, Oliver Friedrich |
Abstract |
Microelectrode array (MEA) technology is a neurophysiological method that allows for the spontaneous measure of activity in neural cultures and determination of drug and chemical effects thereon. Recent introduction of multi-well MEA (mwMEA) formats have dramatically increased the throughput of this technology, allowing more efficient compound screening. Rapid characterization of compounds for neuroactivity or neurotoxicity hazard evaluation following acute, chronic, or developmental exposures ideally would also consider compound effects on cell health, and to do so in the same well requires a multiplexed approach. Procedures describing the multiplexed method to acute and developmental screening are described in this chapter. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 22% |
Researcher | 2 | 22% |
Professor | 1 | 11% |
Other | 1 | 11% |
Student > Master | 1 | 11% |
Other | 1 | 11% |
Unknown | 1 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 3 | 33% |
Biochemistry, Genetics and Molecular Biology | 2 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
Medicine and Dentistry | 1 | 11% |
Mathematics | 1 | 11% |
Other | 0 | 0% |
Unknown | 1 | 11% |