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FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance

Overview of attention for article published in Genetics and Molecular Biology, March 2017
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Title
FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance
Published in
Genetics and Molecular Biology, March 2017
DOI 10.1590/1678-4685-gmb-2016-0115
Pubmed ID
Authors

Viscardi, Lucas Henriques, Tovo-Rodrigues, Luciana, Paré, Pamela, Fagundes, Nelson Jurandi Rosa, Salzano, Francisco Mauro, Paixão-Côrtes, Vanessa Rodrigues, Bau, Claiton Henrique Dotto, Bortolini, Maria Cátira, Viscardi, Lucas Henriques, Tovo-Rodrigues, Luciana, Paré, Pamela, Fagundes, Nelson Jurandi Rosa, Salzano, Francisco Mauro, Paixão-Côrtes, Vanessa Rodrigues, Bau, Claiton Henrique Dotto, Bortolini, Maria Cátira

Abstract

The FOXP subfamily is probably the most extensively characterized subfamily of the forkhead superfamily, playing important roles in development and homeostasis in vertebrates. Intrinsically disorder protein regions (IDRs) are protein segments that exhibit multiple physical interactions and play critical roles in various biological processes, including regulation and signaling. IDRs in proteins may play an important role in the evolvability of genetic systems. In this study, we analyzed 77 orthologous FOXP genes/proteins from Tetrapoda, regarding protein disorder content and evolutionary rate. We also predicted the number and type of short linear motifs (SLIMs) in the IDRs. Similar levels of protein disorder (approximately 70%) were found for FOXP1, FOXP2, and FOXP4. However, for FOXP3, which is shorter in length and has a more specific function, the disordered content was lower (30%). Mammals showed higher protein disorders for FOXP1 and FOXP4 than non-mammals. Specific analyses related to linear motifs in the four genes showed also a clear differentiation between FOXPs in mammals and non-mammals. We predicted for the first time the role of IDRs and SLIMs in the FOXP gene family associated with possible adaptive novelties within Tetrapoda. For instance, we found gain and loss of important phosphorylation sites in the Homo sapiens FOXP2 IDR regions, with possible implication for the evolution of human speech.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 13%
Student > Master 3 13%
Student > Ph. D. Student 3 13%
Student > Postgraduate 2 9%
Researcher 2 9%
Other 3 13%
Unknown 7 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 26%
Biochemistry, Genetics and Molecular Biology 4 17%
Computer Science 1 4%
Earth and Planetary Sciences 1 4%
Sports and Recreations 1 4%
Other 1 4%
Unknown 9 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2017.
All research outputs
#7,536,232
of 9,777,221 outputs
Outputs from Genetics and Molecular Biology
#165
of 258 outputs
Outputs of similar age
#188,629
of 264,161 outputs
Outputs of similar age from Genetics and Molecular Biology
#1
of 3 outputs
Altmetric has tracked 9,777,221 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 258 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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