Title |
Challenges and emerging directions in single-cell analysis
|
---|---|
Published in |
Genome Biology, May 2017
|
DOI | 10.1186/s13059-017-1218-y |
Pubmed ID | |
Authors |
Guo-Cheng Yuan, Long Cai, Michael Elowitz, Tariq Enver, Guoping Fan, Guoji Guo, Rafael Irizarry, Peter Kharchenko, Junhyong Kim, Stuart Orkin, John Quackenbush, Assieh Saadatpour, Timm Schroeder, Ramesh Shivdasani, Itay Tirosh |
Abstract |
Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular information at the individual cell level. Development of single-cell technologies and computational methods has enabled systematic investigation of cellular heterogeneity in a wide range of tissues and cell populations, yielding fresh insights into the composition, dynamics, and regulatory mechanisms of cell states in development and disease. Despite substantial advances, significant challenges remain in the analysis, integration, and interpretation of single-cell omics data. Here, we discuss the state of the field and recent advances and look to future opportunities. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 27% |
United Kingdom | 2 | 18% |
Spain | 1 | 9% |
Canada | 1 | 9% |
Netherlands | 1 | 9% |
Unknown | 3 | 27% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 45% |
Scientists | 5 | 45% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
United States | 2 | <1% |
Unknown | 637 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 153 | 24% |
Researcher | 110 | 17% |
Student > Bachelor | 61 | 10% |
Student > Master | 48 | 7% |
Student > Postgraduate | 32 | 5% |
Other | 98 | 15% |
Unknown | 139 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 190 | 30% |
Agricultural and Biological Sciences | 116 | 18% |
Engineering | 36 | 6% |
Computer Science | 28 | 4% |
Medicine and Dentistry | 24 | 4% |
Other | 86 | 13% |
Unknown | 161 | 25% |