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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice
|
|---|---|
| Published in |
Nature Medicine, May 2017
|
| DOI | 10.1038/nm.4311 |
| Pubmed ID | |
| Authors |
Andras Bilkei-Gorzo, Onder Albayram, Astrid Draffehn, Kerstin Michel, Anastasia Piyanova, Hannah Oppenheimer, Mona Dvir-Ginzberg, Ildiko Rácz, Thomas Ulas, Sophie Imbeault, Itai Bab, Joachim L Schultze, Andreas Zimmer |
| Abstract |
The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes underlying aging. The activity of the ECS declines during aging, as CB1 receptor expression and coupling to G proteins are reduced in the brain tissues of older animals and the levels of the major endocannabinoid 2-arachidonoylglycerol (2-AG) are lower. However, a direct link between endocannabinoid tone and aging symptoms has not been demonstrated. Here we show that a low dose of Δ(9)-tetrahydrocannabinol (THC) reversed the age-related decline in cognitive performance of mice aged 12 and 18 months. This behavioral effect was accompanied by enhanced expression of synaptic marker proteins and increased hippocampal spine density. THC treatment restored hippocampal gene transcription patterns such that the expression profiles of THC-treated mice aged 12 months closely resembled those of THC-free animals aged 2 months. The transcriptional effects of THC were critically dependent on glutamatergic CB1 receptors and histone acetylation, as their inhibition blocked the beneficial effects of THC. Thus, restoration of CB1 signaling in old individuals could be an effective strategy to treat age-related cognitive impairments. |
X Demographics
The data shown below were collected from the profiles of 700 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 108 | 15% |
| Canada | 61 | 9% |
| Japan | 59 | 8% |
| United Kingdom | 24 | 3% |
| Spain | 14 | 2% |
| France | 11 | 2% |
| Brazil | 9 | 1% |
| Mexico | 9 | 1% |
| Germany | 8 | 1% |
| Other | 72 | 10% |
| Unknown | 325 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 593 | 85% |
| Scientists | 64 | 9% |
| Practitioners (doctors, other healthcare professionals) | 33 | 5% |
| Science communicators (journalists, bloggers, editors) | 10 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 529 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Canada | 2 | <1% |
| Chile | 1 | <1% |
| Finland | 1 | <1% |
| Slovenia | 1 | <1% |
| Germany | 1 | <1% |
| Spain | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 518 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 99 | 19% |
| Researcher | 83 | 16% |
| Student > Bachelor | 63 | 12% |
| Student > Master | 62 | 12% |
| Student > Doctoral Student | 33 | 6% |
| Other | 78 | 15% |
| Unknown | 111 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 103 | 19% |
| Agricultural and Biological Sciences | 85 | 16% |
| Biochemistry, Genetics and Molecular Biology | 59 | 11% |
| Medicine and Dentistry | 49 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 26 | 5% |
| Other | 86 | 16% |
| Unknown | 121 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1938. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2024.
All research outputs
#4,949
of 25,734,859 outputs
Outputs from Nature Medicine
#84
of 9,412 outputs
Outputs of similar age
#62
of 325,728 outputs
Outputs of similar age from Nature Medicine
#1
of 66 outputs
Altmetric has tracked 25,734,859 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,412 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 106.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,728 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.