↓ Skip to main content

Th9 Cells

Overview of attention for book
Cover of 'Th9 Cells'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Th9 Cells: New Member of T Helper Cell Family
  3. Altmetric Badge
    Chapter 2 IL-9: Function, Sources, and Detection
  4. Altmetric Badge
    Chapter 3 IL-9 Signaling Pathway: An Update
  5. Altmetric Badge
    Chapter 4 A Method to In Vitro Differentiate Th9 Cells from Mouse Naïve CD4+ T Cells
  6. Altmetric Badge
    Chapter 5 T Cell Receptor and Co-Stimulatory Signals for Th9 Generation
  7. Altmetric Badge
    Chapter 6 Polarizing Cytokines for Human Th9 Cell Differentiation
  8. Altmetric Badge
    Chapter 7 Determining the Frequencies of Th9 Cells from Whole Blood
  9. Altmetric Badge
    Chapter 8 IL-9 Production by Nonconventional T helper Cells
  10. Altmetric Badge
    Chapter 9 Prediction and Validation of Transcription Factors Binding Sites in the Il9 Locus
  11. Altmetric Badge
    Chapter 10 Flow Cytometric Assessment of STAT Molecules in Th9 Cells
  12. Altmetric Badge
    Chapter 11 Transcription Factors Downstream of IL-4 and TGF-β Signals: Analysis by Quantitative PCR, Western Blot, and Flow Cytometry
  13. Altmetric Badge
    Chapter 12 Retroviral Transduction and Reporter Assay: Transcription Factor Cooperation in Th9 Cell Development
  14. Altmetric Badge
    Chapter 13 Transcription Factor Binding Studies in CD4+ T Cells: siRNA Transfection, Chromatin Immunoprecipitation, and Liquid Luminescent DNA Precipitation Assay
  15. Altmetric Badge
    Chapter 14 Defining Epigenetic Regulation of the Interleukin-9 Gene by Chromatin Immunoprecipitation
  16. Altmetric Badge
    Chapter 15 Allergic Inflammation and Atopic Disease: Role of Th9 Cells
  17. Altmetric Badge
    Chapter 16 Characterization of Th9 Cells in the Development of EAE and IBD
  18. Altmetric Badge
    Chapter 17 B16 Lung Melanoma Model to Study the Role of Th9 Cells in Cancer
  19. Altmetric Badge
    Chapter 18 Th9 Cells and Parasitic Inflammation: Use of Nippostrongylus and Schistosoma Models
  20. Altmetric Badge
    Chapter 19 Isolation and Purification of Th9 Cells for the Study of Inflammatory Diseases in Research and Clinical Settings
Attention for Chapter 19: Isolation and Purification of Th9 Cells for the Study of Inflammatory Diseases in Research and Clinical Settings
Altmetric Badge

Citations

dimensions_citation
1 Dimensions

Readers on

mendeley
9 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Isolation and Purification of Th9 Cells for the Study of Inflammatory Diseases in Research and Clinical Settings
Chapter number 19
Book title
Th9 Cells
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6877-0_19
Pubmed ID
Book ISBNs
978-1-4939-6876-3, 978-1-4939-6877-0
Authors

Patricia Keating Ph.D., James X. Hartmann Ph.D., Patricia Keating, James X. Hartmann

Editors

Ritobrata Goswami

Abstract

Th9 cells are associated with atopic and inflammatory diseases, and their increased levels and function correlate with the severity of symptoms in various inflammatory disorders including asthma, food allergy, atopic dermatitis, ulcerative colitis, and psoriatic arthritis. Thus, clinical trials are warranted to evaluate the role of Th9 cells in allergic diseases with the goal of controlling these ailments.Circulating T cells (naïve or memory CD4+ T cells) purified from human blood and expanded using anti-CD3 and anti-CD28 antibodies can be treated with appropriate cytokines in order to polarize them to the Th9 phenotype as evidenced by their production of IL-9. When treated in vitro with cholecalciferol or 1,25(OH)2 vitamin D3, cells polarized under Th9 conditions significantly downregulate production of IL-9. The percentage of polarized Th9 memory cells from patients treated with steroids or other modalities can be monitored during clinical trials and compared to control populations.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 22%
Professor 2 22%
Student > Bachelor 1 11%
Student > Doctoral Student 1 11%
Student > Ph. D. Student 1 11%
Other 2 22%
Readers by discipline Count As %
Medicine and Dentistry 5 56%
Immunology and Microbiology 2 22%
Nursing and Health Professions 1 11%
Unknown 1 11%