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Alleles of the homologous recombination gene, RAD59, identify multiple responses to disrupted DNA replication in Saccharomyces cerevisiae

Overview of attention for article published in BMC Microbiology, January 2013
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Title
Alleles of the homologous recombination gene, RAD59, identify multiple responses to disrupted DNA replication in Saccharomyces cerevisiae
Published in
BMC Microbiology, January 2013
DOI 10.1186/1471-2180-13-229
Pubmed ID
Authors

Lauren C Liddell, Glenn M Manthey, Shannon N Owens, Becky XH Fu, Adam M Bailis

Abstract

In Saccharomyces cerevisiae, Rad59 is required for multiple homologous recombination mechanisms and viability in DNA replication-defective rad27 mutant cells. Recently, four rad59 missense alleles were found to have distinct effects on homologous recombination that are consistent with separation-of-function mutations. The rad59-K166A allele alters an amino acid in a conserved α-helical domain, and, like the rad59 null allele diminishes association of Rad52 with double-strand breaks. The rad59-K174A and rad59-F180A alleles alter amino acids in the same domain and have genetically similar effects on homologous recombination. The rad59-Y92A allele alters a conserved amino acid in a separate domain, has genetically distinct effects on homologous recombination, and does not diminish association of Rad52 with double-strand breaks.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 27%
Professor 1 9%
Student > Doctoral Student 1 9%
Student > Ph. D. Student 1 9%
Lecturer > Senior Lecturer 1 9%
Other 1 9%
Unknown 3 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 36%
Agricultural and Biological Sciences 3 27%
Immunology and Microbiology 1 9%
Unknown 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2013.
All research outputs
#10,994,894
of 12,372,633 outputs
Outputs from BMC Microbiology
#1,462
of 1,804 outputs
Outputs of similar age
#187,837
of 225,489 outputs
Outputs of similar age from BMC Microbiology
#88
of 109 outputs
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