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RT @Doctor_IMF: I suspect these MSH2 missense VUS are the legacy variants that we, that is InSiGHT have not got round to curating yet. It w…
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RT @Doctor_IMF: I suspect these MSH2 missense VUS are the legacy variants that we, that is InSiGHT have not got round to curating yet. It w…
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I suspect these MSH2 missense VUS are the legacy variants that we, that is InSiGHT have not got round to curating yet. It would be interesting to see how this analysis tallies with the prior probabilities of pathogenicity in https://t.co/5bMtc6d7SS used in
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@kevinjmonahan @Adductor @PBenusiglio @uk_biobank @JAMANetworkOpen @TMSnowsill Ok, no wonder, as our criteria are hugely more nuanced and sophisticated. When introduced we reduced VUSs by a third, and the InSiGHT Variant Interpretation Committee is the bur