RT @KarrsJeremiah: @SibaElHussein have you seen any cases w/ CXCR4, but w/out MYD88? Was reading https://t.co/xe4PrespDk they usually co-oc…
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@SibaElHussein have you seen any cases w/ CXCR4, but w/out MYD88? Was reading https://t.co/xe4PrespDk they usually co-occur, but had a recent low-grade B-cell lymphoma case w/ just a CXCR4 mutation (no MYD88). CXCR4 isn't specific according to WHO, but cur
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The L265P MYD88 mutation is present in >90% of LPL, whilst CXCR4 is present in about 25-30%: https://t.co/Dg8am6biI0 The L265P is not specific for LPL as it can be seen in DLBCL, but in the context of the IgM paraprotein and morphology, it supports a d
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#Waldenströmmacroglobulinemia &MYD88&WHIM-like CXCR4 mutations&small somatic deletions http://t.co/8oJbEgR6JN