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Effect of eccentric training on mitochondrial function and oxidative stress in the skeletal muscle of rats

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2013
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Title
Effect of eccentric training on mitochondrial function and oxidative stress in the skeletal muscle of rats
Published in
Brazilian Journal of Medical and Biological Research, January 2013
DOI 10.1590/1414-431x20121956
Pubmed ID
Authors

L.A. Silva, K.F. Bom, C.B. Tromm, G.L. Rosa, I. Mariano, B.G. Pozzi, T. Tuon, E.L. Stresck, C.T. Souza, R.A. Pinho

Abstract

The objective of the present study was to investigate the effects of eccentric training on the activity of mitochondrial respiratory chain enzymes, oxidative stress, muscle damage, and inflammation of skeletal muscle. Eighteen male mice (CF1) weighing 30-35 g were randomly divided into 3 groups (N = 6): untrained, trained eccentric running (16°; TER), and trained running (0°) (TR), and were submitted to an 8-week training program. TER increased muscle oxidative capacity (succinate dehydrogenase and complexes I and II) in a manner similar to TR, and TER did not decrease oxidative damage (xylenol and creatine phosphate) but increased antioxidant enzyme activity (superoxide dismutase and catalase) similar to TR. Muscle damage (creatine kinase) and inflammation (myeloperoxidase) were not reduced by TER. In conclusion, we suggest that TER improves mitochondrial function but does not reduce oxidative stress, muscle damage, or inflammation induced by eccentric contractions.

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Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Brazil 1 3%
Unknown 34 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 19%
Student > Bachelor 5 14%
Student > Ph. D. Student 4 11%
Professor 4 11%
Student > Postgraduate 2 6%
Other 9 25%
Unknown 5 14%
Readers by discipline Count As %
Sports and Recreations 10 28%
Biochemistry, Genetics and Molecular Biology 7 19%
Agricultural and Biological Sciences 5 14%
Medicine and Dentistry 4 11%
Social Sciences 2 6%
Other 3 8%
Unknown 5 14%