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Mendeley readers
Attention Score in Context
| Title |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults
|
|---|---|
| Published in |
Revista Brasileira de Psiquiatria, January 2017
|
| DOI | 10.1590/1516-4446-2016-1980 |
| Pubmed ID | |
| Authors |
Lucas A. de Azeredo, Tatiana De Nardi, Mateus L. Levandowski, Saulo G. Tractenberg, Julia Kommers-Molina, Andrea Wieck, Tatiana Q. Irigaray, Irênio G. da Silva, Rodrigo Grassi-Oliveira |
| Abstract |
Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 85 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 13% |
| Researcher | 11 | 13% |
| Student > Doctoral Student | 11 | 13% |
| Student > Master | 10 | 12% |
| Unspecified | 9 | 11% |
| Other | 16 | 19% |
| Unknown | 17 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 16% |
| Medicine and Dentistry | 11 | 13% |
| Unspecified | 9 | 11% |
| Psychology | 8 | 9% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Other | 15 | 18% |
| Unknown | 22 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2017.
All research outputs
#17,534,407
of 25,707,225 outputs
Outputs from Revista Brasileira de Psiquiatria
#535
of 905 outputs
Outputs of similar age
#271,330
of 425,728 outputs
Outputs of similar age from Revista Brasileira de Psiquiatria
#8
of 15 outputs
Altmetric has tracked 25,707,225 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 905 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.