↓ Skip to main content

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

Overview of attention for article published in Revista Brasileira de Psiquiatria, January 2017
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
71 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults
Published in
Revista Brasileira de Psiquiatria, January 2017
DOI 10.1590/1516-4446-2016-1980
Pubmed ID
Authors

Lucas A. de Azeredo, Tatiana De Nardi, Mateus L. Levandowski, Saulo G. Tractenberg, Julia Kommers-Molina, Andrea Wieck, Tatiana Q. Irigaray, Irênio G. da Silva Filho, Rodrigo Grassi-Oliveira

Abstract

Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 71 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 14%
Student > Master 10 14%
Student > Doctoral Student 10 14%
Researcher 9 13%
Student > Bachelor 7 10%
Other 9 13%
Unknown 16 23%
Readers by discipline Count As %
Neuroscience 14 20%
Medicine and Dentistry 9 13%
Psychology 7 10%
Biochemistry, Genetics and Molecular Biology 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Other 11 15%
Unknown 21 30%