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Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder

Overview of attention for article published in BMC Veterinary Research, December 2013
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Title
Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder
Published in
BMC Veterinary Research, December 2013
DOI 10.1186/1746-6148-9-262
Pubmed ID
Authors

Felix K Gesell, Alexander A Zoerner, Christina Brauer, Stefan Engeli, Dimitros Tsikas, Andrea Tipold

Abstract

Epilepsy is one of the most common chronic neurological disorders in dogs characterized by recurrent seizures. The endocannabinoid (EC) system plays a central role in suppressing pathologic neuronal excitability and in controlling the spread of activity in an epileptic network. Endocannabinoids are released on demand and their dysregulation has been described in several pathological conditions. Recurrent seizures may lead to an adverse reorganization of the EC system and impairment of its protective effect. In the current study, we tested the hypothesis that cerebrospinal fluid (CSF) concentrations of the endocannabinoids anandamide (AEA) and 2-arachidonoyl glycerol (2AG) are altered in epileptic dogs. Concentrations of AEA and total AG (sum of 2AG and 1AG) were measured in 40 dogs with idiopathic epilepsy and in 16 unaffected, healthy control dogs using liquid chromatography combined with tandem mass spectrometry.

X Demographics

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 84 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 16%
Researcher 8 9%
Student > Ph. D. Student 8 9%
Student > Bachelor 8 9%
Other 7 8%
Other 18 21%
Unknown 22 26%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 21 25%
Agricultural and Biological Sciences 11 13%
Medicine and Dentistry 9 11%
Biochemistry, Genetics and Molecular Biology 6 7%
Neuroscience 6 7%
Other 9 11%
Unknown 23 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2015.
All research outputs
#16,721,208
of 25,373,627 outputs
Outputs from BMC Veterinary Research
#1,360
of 3,298 outputs
Outputs of similar age
#197,815
of 320,899 outputs
Outputs of similar age from BMC Veterinary Research
#28
of 54 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,298 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,899 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.