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Screening for primary aldosteronism using the newly developed IDS-iSYS® automated assay system

Overview of attention for article published in Practical Laboratory Medicine , April 2017
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Title
Screening for primary aldosteronism using the newly developed IDS-iSYS® automated assay system
Published in
Practical Laboratory Medicine , April 2017
DOI 10.1016/j.plabm.2016.11.002
Pubmed ID
Authors

P.M. O’Shea, T.P. Griffin, G.A. Browne, N. Gallagher, J.J. Brady, M.C. Dennedy, M. Bell, D. Wall, M. Fitzgibbon

Abstract

The recommended approach to screening for primary aldosteronism (PA) in at-risk populations is to determine the ratio of aldosterone concentration (serum (SAC)/plasma (PAC)) to renin measured in plasma as activity (PRA) or concentration (DRC). However, lack of assay standardisation mandates the need for method-specific decision thresholds and clinical validation in the local population. The study objective was to establish method-specific aldosterone: renin ratio (ARR) cut-offs for PA in men and women using the IDS-iSYS® assay system (IDS plc). A prospective cohort study design was used. PAC and DRC were measured immunochemically in ethylenediamine-tetraacetic acid (EDTA) plasma on the IDS-iSYS® instrument. A total of 437 subjects (218 men, 219 women) were recruited including: healthy normotensive volunteers (n=266) and women taking the oral contraceptive pill (OCP; n=15); patients with essential hypertension (EH; n=128); confirmed PA (n=16); adrenal cortical carcinoma (ACC; n=3); Addison's disease (AD; n=4) and phaeochromocytoma/paraganglioma (PPGL; n=5). In this population, an ARR cut-off at >37.4 pmol/mIU provided 100% diagnostic sensitivity, 96% specificity and positive likelihood ratio for PA of 23:1. When the ARR decision threshold was stratified according to gender, a cut-off of >26.1 pmol/mIU in men and >113.6 pmol/mIU in women resulted in diagnostic sensitivity and specificity of 100%. This study demonstrates that decision thresholds for PA should not only be method-specific but also gender-specific. However, given the small number of PA patients (n=16), particularly women (n=4), further validation through a prospective study with a larger PA cohort is required before the thresholds presented here could be recommended for routine clinical use.

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Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 21%
Student > Bachelor 5 17%
Student > Master 4 14%
Researcher 4 14%
Student > Ph. D. Student 2 7%
Other 4 14%
Unknown 4 14%
Readers by discipline Count As %
Medicine and Dentistry 13 45%
Biochemistry, Genetics and Molecular Biology 4 14%
Business, Management and Accounting 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Social Sciences 1 3%
Other 3 10%
Unknown 6 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2017.
All research outputs
#9,781,273
of 12,241,449 outputs
Outputs from Practical Laboratory Medicine
#15
of 30 outputs
Outputs of similar age
#191,283
of 267,345 outputs
Outputs of similar age from Practical Laboratory Medicine
#4
of 6 outputs
Altmetric has tracked 12,241,449 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 30 research outputs from this source. They receive a mean Attention Score of 3.3. This one scored the same or higher as 15 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,345 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.