| Title |
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice
|
|---|---|
| Published in |
Nature Communications, May 2017
|
| DOI | 10.1038/ncomms15261 |
| Pubmed ID | |
| Authors |
Monica M. Laronda, Alexandra L. Rutz, Shuo Xiao, Kelly A. Whelan, Francesca E. Duncan, Eric W. Roth, Teresa K. Woodruff, Ramille N. Shah |
| Abstract |
Emerging additive manufacturing techniques enable investigation of the effects of pore geometry on cell behavior and function. Here, we 3D print microporous hydrogel scaffolds to test how varying pore geometry, accomplished by manipulating the advancing angle between printed layers, affects the survival of ovarian follicles. 30° and 60° scaffolds provide corners that surround follicles on multiple sides while 90° scaffolds have an open porosity that limits follicle-scaffold interaction. As the amount of scaffold interaction increases, follicle spreading is limited and survival increases. Follicle-seeded scaffolds become highly vascularized and ovarian function is fully restored when implanted in surgically sterilized mice. Moreover, pups are born through natural mating and thrive through maternal lactation. These findings present an in vivo functional ovarian implant designed with 3D printing, and indicate that scaffold pore architecture is a critical variable in additively manufactured scaffold design for functional tissue engineering. |
X Demographics
The data shown below were collected from the profiles of 367 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 87 | 24% |
| United Kingdom | 38 | 10% |
| Canada | 18 | 5% |
| Brazil | 11 | 3% |
| Australia | 9 | 2% |
| France | 8 | 2% |
| Spain | 7 | 2% |
| Mexico | 5 | 1% |
| Japan | 5 | 1% |
| Other | 44 | 12% |
| Unknown | 135 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 262 | 71% |
| Scientists | 77 | 21% |
| Practitioners (doctors, other healthcare professionals) | 15 | 4% |
| Science communicators (journalists, bloggers, editors) | 13 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 623 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| Malaysia | 1 | <1% |
| Spain | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 618 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 127 | 20% |
| Student > Master | 82 | 13% |
| Student > Bachelor | 75 | 12% |
| Researcher | 70 | 11% |
| Student > Doctoral Student | 34 | 5% |
| Other | 86 | 14% |
| Unknown | 149 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 95 | 15% |
| Biochemistry, Genetics and Molecular Biology | 93 | 15% |
| Agricultural and Biological Sciences | 71 | 11% |
| Medicine and Dentistry | 56 | 9% |
| Materials Science | 33 | 5% |
| Other | 101 | 16% |
| Unknown | 174 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2252. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2024.
All research outputs
#3,768
of 25,782,917 outputs
Outputs from Nature Communications
#62
of 58,435 outputs
Outputs of similar age
#36
of 326,277 outputs
Outputs of similar age from Nature Communications
#3
of 1,044 outputs
Altmetric has tracked 25,782,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,435 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 1,044 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.