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A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice

Overview of attention for article published in Nature Communications, May 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#7 of 26,898)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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135 Dimensions

Readers on

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371 Mendeley
Title
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice
Published in
Nature Communications, May 2017
DOI 10.1038/ncomms15261
Pubmed ID
Authors

Monica M. Laronda, Alexandra L. Rutz, Shuo Xiao, Kelly A. Whelan, Francesca E. Duncan, Eric W. Roth, Teresa K. Woodruff, Ramille N. Shah

Abstract

Emerging additive manufacturing techniques enable investigation of the effects of pore geometry on cell behavior and function. Here, we 3D print microporous hydrogel scaffolds to test how varying pore geometry, accomplished by manipulating the advancing angle between printed layers, affects the survival of ovarian follicles. 30° and 60° scaffolds provide corners that surround follicles on multiple sides while 90° scaffolds have an open porosity that limits follicle-scaffold interaction. As the amount of scaffold interaction increases, follicle spreading is limited and survival increases. Follicle-seeded scaffolds become highly vascularized and ovarian function is fully restored when implanted in surgically sterilized mice. Moreover, pups are born through natural mating and thrive through maternal lactation. These findings present an in vivo functional ovarian implant designed with 3D printing, and indicate that scaffold pore architecture is a critical variable in additively manufactured scaffold design for functional tissue engineering.

Twitter Demographics

The data shown below were collected from the profiles of 446 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 371 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 <1%
Germany 2 <1%
Malaysia 1 <1%
Italy 1 <1%
Unknown 365 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 98 26%
Student > Master 55 15%
Student > Bachelor 45 12%
Researcher 44 12%
Student > Doctoral Student 25 7%
Other 55 15%
Unknown 49 13%
Readers by discipline Count As %
Engineering 61 16%
Biochemistry, Genetics and Molecular Biology 60 16%
Agricultural and Biological Sciences 58 16%
Medicine and Dentistry 42 11%
Materials Science 24 6%
Other 58 16%
Unknown 68 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2308. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2020.
All research outputs
#659
of 14,367,330 outputs
Outputs from Nature Communications
#7
of 26,898 outputs
Outputs of similar age
#30
of 266,171 outputs
Outputs of similar age from Nature Communications
#2
of 1,100 outputs
Altmetric has tracked 14,367,330 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,898 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,171 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,100 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.