↓ Skip to main content

Preexisting CD8 + T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, January 2014
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
4 news outlets
blogs
2 blogs
twitter
15 tweeters
patent
1 patent
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
126 Dimensions

Readers on

mendeley
137 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Preexisting CD8 + T-cell immunity to the H7N9 influenza A virus varies across ethnicities
Published in
Proceedings of the National Academy of Sciences of the United States of America, January 2014
DOI 10.1073/pnas.1322229111
Pubmed ID
Authors

Sergio Quiñones-Parra, Emma Grant, Liyen Loh, Thi H. O. Nguyen, Kristy-Anne Campbell, Steven Y. C. Tong, Adrian Miller, Peter C. Doherty, Dhanasekaran Vijaykrishna, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska

Abstract

The absence of preexisting neutralizing antibodies specific for the novel A (H7N9) influenza virus indicates a lack of prior human exposure. As influenza A virus-specific CD8(+) T lymphocytes (CTLs) can be broadly cross-reactive, we tested whether immunogenic peptides derived from H7N9 might be recognized by memory CTLs established following infection with other influenza strains. Probing across multiple ethnicities, we identified 32 conserved epitopes derived from the nucleoprotein (NP) and matrix-1 (M1) proteins. These NP and M1 peptides are presented by HLAs prevalent in 16-57% of individuals. Remarkably, some HLA alleles (A*0201, A*0301, B*5701, B*1801, and B*0801) elicit robust CTL responses against any human influenza A virus, including H7N9, whereas ethnicities where HLA-A*0101, A*6801, B*1501, and A*2402 are prominent, show limited CTL response profiles. By this criterion, some groups, especially the Alaskan and Australian Indigenous peoples, would be particularly vulnerable to H7N9 infection. This dissection of CTL-mediated immunity to H7N9 thus suggests strategies for both vaccine delivery and development.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 2 1%
Hungary 1 <1%
United Kingdom 1 <1%
Saudi Arabia 1 <1%
Singapore 1 <1%
Unknown 131 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 23%
Student > Ph. D. Student 27 20%
Student > Bachelor 26 19%
Student > Master 14 10%
Other 6 4%
Other 18 13%
Unknown 15 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 56 41%
Medicine and Dentistry 17 12%
Biochemistry, Genetics and Molecular Biology 15 11%
Immunology and Microbiology 15 11%
Mathematics 3 2%
Other 14 10%
Unknown 17 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 59. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2021.
All research outputs
#549,057
of 21,224,592 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#10,105
of 95,418 outputs
Outputs of similar age
#6,942
of 303,505 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#140
of 965 outputs
Altmetric has tracked 21,224,592 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 95,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 303,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 965 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.