↓ Skip to main content

Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, January 2014
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
4 news outlets
blogs
2 blogs
twitter
18 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
85 Dimensions

Readers on

mendeley
107 Mendeley
citeulike
1 CiteULike
Title
Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities
Published in
Proceedings of the National Academy of Sciences of the United States of America, January 2014
DOI 10.1073/pnas.1322229111
Pubmed ID
Authors

S. Quinones-Parra, E. Grant, L. Loh, T. H. O. Nguyen, K.-A. Campbell, S. Y. C. Tong, A. Miller, P. C. Doherty, D. Vijaykrishna, J. Rossjohn, S. Gras, K. Kedzierska

Abstract

The absence of preexisting neutralizing antibodies specific for the novel A (H7N9) influenza virus indicates a lack of prior human exposure. As influenza A virus-specific CD8(+) T lymphocytes (CTLs) can be broadly cross-reactive, we tested whether immunogenic peptides derived from H7N9 might be recognized by memory CTLs established following infection with other influenza strains. Probing across multiple ethnicities, we identified 32 conserved epitopes derived from the nucleoprotein (NP) and matrix-1 (M1) proteins. These NP and M1 peptides are presented by HLAs prevalent in 16-57% of individuals. Remarkably, some HLA alleles (A*0201, A*0301, B*5701, B*1801, and B*0801) elicit robust CTL responses against any human influenza A virus, including H7N9, whereas ethnicities where HLA-A*0101, A*6801, B*1501, and A*2402 are prominent, show limited CTL response profiles. By this criterion, some groups, especially the Alaskan and Australian Indigenous peoples, would be particularly vulnerable to H7N9 infection. This dissection of CTL-mediated immunity to H7N9 thus suggests strategies for both vaccine delivery and development.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 2 2%
United Kingdom 1 <1%
Hungary 1 <1%
Saudi Arabia 1 <1%
Unknown 102 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 24 22%
Student > Ph. D. Student 24 22%
Researcher 20 19%
Unspecified 8 7%
Student > Master 8 7%
Other 19 18%
Unknown 4 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 55 51%
Medicine and Dentistry 11 10%
Unspecified 9 8%
Biochemistry, Genetics and Molecular Biology 8 7%
Immunology and Microbiology 6 6%
Other 14 13%
Unknown 4 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 57. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2014.
All research outputs
#277,372
of 12,861,153 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#6,238
of 78,874 outputs
Outputs of similar age
#5,532
of 249,579 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#134
of 945 outputs
Altmetric has tracked 12,861,153 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 78,874 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.9. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,579 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 945 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.