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The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine

Overview of attention for article published in Anais da Academia Brasileira de Ciências, May 2017
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Title
The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine
Published in
Anais da Academia Brasileira de Ciências, May 2017
DOI 10.1590/0001-3765201720160490
Pubmed ID
Authors

LOUYSE S. DAMAZIO, FLÁVIA R. SILVEIRA, LARA CANEVER, ADALBERTO A. DE CASTRO, JADNE M. ESTRELA, JOSIANE BUDNI, ALEXANDRA I. ZUGNO

Abstract

Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) in an animal model of schizophrenia (SZ). Rats were supplemented with AA (0.1, 1, or 10 mg/kg), or water for 14 days (gavage). Between the 9th and 15th days, the animals received Ketamine (Ket) (25 mg/kg) or saline (i.p). After the last administration (30 min) rats were subjected to the behavioral test. Brain structures were dissected for biochemical analysis. There was a significant increase in the locomotor activity in Ket treated. AA prevented the hyperlocomotion induced by ket. Ket also showed an increase of AChE activity within the prefrontal cortex and striatum prevented by AA. Our data indicates an effect for AA in preventing alterations induced by Ket in an animal model of SZ, suggesting that it may be an adjuvant approach for the development of new therapeutic strategies within this psychiatric disorder.

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 20%
Researcher 3 15%
Professor 2 10%
Student > Doctoral Student 2 10%
Student > Master 2 10%
Other 1 5%
Unknown 6 30%
Readers by discipline Count As %
Neuroscience 6 30%
Nursing and Health Professions 2 10%
Computer Science 1 5%
Agricultural and Biological Sciences 1 5%
Medicine and Dentistry 1 5%
Other 1 5%
Unknown 8 40%