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Chlorhexidine with or without alcohol against biofilm formation: efficacy, adverse events and taste preference

Overview of attention for article published in Brazilian Oral Research, May 2017
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Title
Chlorhexidine with or without alcohol against biofilm formation: efficacy, adverse events and taste preference
Published in
Brazilian Oral Research, May 2017
DOI 10.1590/1807-3107bor-2017.vol31.0032
Pubmed ID
Authors

Gabriela Otero dos SANTOS, Fernanda Carpes MILANESI, Bruna Frizon GREGGIANIN, Marilene Issa FERNANDES, Rui Vicente OPPERMANN, Patricia WEIDLICH

Abstract

In recent years, different chlorhexidine formulations have been tested, including an alcohol-free alternative, but the effect of this solution on early biofilm formation is not clear. A crossover, randomized, double-blind clinical trial was conducted to evaluate the effect of two chlorhexidine solutions against supra- and subgingival biofilm formation (NCT#02656251). Thirty-five participants were randomized and asked to rinse twice daily with 15 ml of an alcohol-containing 0.12% chlorhexidine solution, an alcohol-free 0.12% chlorhexidine solution, or placebo. The study was conducted in three experimental periods of 4 days each, with a 10-day washout between the periods. All the experimental periods followed the same protocol, except that the solutions were switched. Biofilm distribution was evaluated every 24 hours by the Plaque-Free Zone Index, during 96 hours. Adverse events were self-reported and sensory evaluation was performed using a hedonic scale. Compared to the placebo, the chlorhexidine solutions resulted in a significantly higher number of surfaces free of plaque over 96 hours (p < 0.01), and were able to prevent subgingival biofilm formation (p < 0.01). The alcohol-free chlorhexidine solution was associated with a lower incidence of adverse events, compared with alcohol-containing chlorhexidine (p < 0.05); it also received better sensory evaluation and acceptance by trial participants, compared with the alcohol-containing chlorhexidine (p = 0.007), and had a similar inhibitory effect on the formation of supra- and subgingival biofilms.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 69 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 15 22%
Student > Master 14 20%
Student > Postgraduate 6 9%
Researcher 6 9%
Student > Ph. D. Student 5 7%
Other 5 7%
Unknown 18 26%
Readers by discipline Count As %
Medicine and Dentistry 30 43%
Immunology and Microbiology 4 6%
Biochemistry, Genetics and Molecular Biology 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Nursing and Health Professions 2 3%
Other 6 9%
Unknown 21 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2017.
All research outputs
#9,175,925
of 10,451,113 outputs
Outputs from Brazilian Oral Research
#113
of 143 outputs
Outputs of similar age
#218,881
of 263,097 outputs
Outputs of similar age from Brazilian Oral Research
#1
of 1 outputs
Altmetric has tracked 10,451,113 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 143 research outputs from this source. They receive a mean Attention Score of 1.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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