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A molecular brake controls the magnitude of long-term potentiation

Overview of attention for article published in Nature Communications, January 2014
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Title
A molecular brake controls the magnitude of long-term potentiation
Published in
Nature Communications, January 2014
DOI 10.1038/ncomms4051
Pubmed ID
Authors

Yubin Wang, Guoqi Zhu, Victor Briz, Yu-Tien Hsu, Xiaoning Bi, Michel Baudry

Abstract

Overexpression of suprachiasmatic nucleus circadian oscillatory protein (SCOP), a negative ERK regulator, blocks long-term memory encoding. Inhibition of calpain-mediated SCOP degradation also prevents the formation of long-term memory, suggesting rapid SCOP breakdown is necessary for memory encoding. However, whether SCOP levels also control the magnitude of long-term synaptic plasticity is unknown. Here we show that following synaptic activity-induced SCOP degradation, SCOP is rapidly replaced via mTOR-mediated protein synthesis. We further show that early SCOP degradation is specifically catalysed by μ-calpain, whereas late SCOP resynthesis is mediated by m-calpain. We propose that μ-calpain promotes long-term potentiation induction by degrading SCOP and activating ERK, whereas m-calpain activation limits the magnitude of potentiation by terminating the ERK response via enhanced SCOP synthesis. This unique braking mechanism could account for the advantages of spaced versus massed training in the formation of long-term memory.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
France 1 2%
Unknown 39 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 32%
Student > Ph. D. Student 10 24%
Student > Doctoral Student 5 12%
Other 3 7%
Professor > Associate Professor 3 7%
Other 5 12%
Unknown 2 5%
Readers by discipline Count As %
Neuroscience 15 37%
Agricultural and Biological Sciences 13 32%
Psychology 3 7%
Biochemistry, Genetics and Molecular Biology 3 7%
Medicine and Dentistry 2 5%
Other 2 5%
Unknown 3 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2014.
All research outputs
#13,672,937
of 17,814,645 outputs
Outputs from Nature Communications
#31,887
of 35,200 outputs
Outputs of similar age
#187,102
of 276,273 outputs
Outputs of similar age from Nature Communications
#625
of 724 outputs
Altmetric has tracked 17,814,645 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 35,200 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 52.4. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,273 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 724 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.