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X Demographics
Mendeley readers
Attention Score in Context
| Title |
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
|
|---|---|
| Published in |
Genome Integrity, December 2013
|
| DOI | 10.1186/2041-9414-4-6 |
| Pubmed ID | |
| Authors |
Augustin Luna, Mirit I Aladjem, Kurt W Kohn |
| Abstract |
An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates, including regulators of DNA damage response and circadian rhythms. We review this complex network using an interactive Molecular Interaction Map (MIM) to explore the interplay between these two proteins. Here we discuss how NAD + competition and post-transcriptional/translational feedback mechanisms create a regulatory network sensitive to environmental cues, such as genotoxic stress and metabolic states, and examine the role of those interactions in DNA repair and ultimately, cell fate decisions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Japan | 1 | <1% |
| Estonia | 1 | <1% |
| Ukraine | 1 | <1% |
| Unknown | 99 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 26% |
| Researcher | 15 | 14% |
| Student > Master | 10 | 10% |
| Student > Doctoral Student | 7 | 7% |
| Student > Bachelor | 7 | 7% |
| Other | 17 | 16% |
| Unknown | 21 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 28% |
| Biochemistry, Genetics and Molecular Biology | 22 | 21% |
| Medicine and Dentistry | 9 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Neuroscience | 3 | 3% |
| Other | 12 | 12% |
| Unknown | 25 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2018.
All research outputs
#7,355,930
of 25,374,647 outputs
Outputs from Genome Integrity
#18
of 38 outputs
Outputs of similar age
#80,745
of 320,465 outputs
Outputs of similar age from Genome Integrity
#1
of 1 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 38 research outputs from this source. They receive a mean Attention Score of 3.9. This one scored the same or higher as 20 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,465 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them