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Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis

Overview of attention for article published in Journals of Gerontology Series A: Biological Sciences & Medical Sciences, May 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#16 of 2,457)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
27 news outlets
blogs
3 blogs
twitter
49 tweeters
facebook
1 Facebook page
reddit
1 Redditor

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
73 Mendeley
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Title
Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis
Published in
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, May 2017
DOI 10.1093/gerona/glx096
Pubmed ID
Authors

Daniel W Belsky, Kim M Huffman, Carl F Pieper, Idan Shalev, William E Kraus

Abstract

Biological aging measures have been proposed as proxies for extension of healthy lifespan in trials of geroprotective therapies that aim to slow aging. Several methods to measure biological aging show promise; but it is not known if these methods are sensitive to changes caused by geroprotective therapy. We conducted analysis of two proposed methods to quantify biological aging using data from a recently concluded trial of an established geroprotector, caloric restriction. We obtained data from the National Institute on Aging CALERIE randomized trial through its public-access biobank (https://calerie.duke.edu/). The CALERIE trial randomized N=220 non-obese adults to 25% caloric restriction (n=145; 11.7% caloric restriction was achieved, on average) or to maintain current diet (n=75) for two years. We analyzed biomarker data collected at baseline, 12-, and 24-month follow-up assessments. We applied published biomarker algorithms to these data to calculate two biological age measures, Klemera-Doubal Method Biological Age and homeostatic dysregulation. Intent-to-treat analysis using mixed-effects growth models of within-person change over time tested if caloric restriction slowed increase in measures of biological aging across follow-up. Analyses of both measures indicated caloric restriction slowed biological aging. Weight loss did not account for the observed effects. Results suggest future directions for testing of geroprotective therapies in humans.

Twitter Demographics

The data shown below were collected from the profiles of 49 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 22%
Student > Ph. D. Student 12 16%
Student > Master 10 14%
Student > Bachelor 8 11%
Professor 5 7%
Other 10 14%
Unknown 12 16%
Readers by discipline Count As %
Medicine and Dentistry 12 16%
Biochemistry, Genetics and Molecular Biology 11 15%
Agricultural and Biological Sciences 10 14%
Nursing and Health Professions 6 8%
Immunology and Microbiology 3 4%
Other 13 18%
Unknown 18 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 253. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2019.
All research outputs
#48,622
of 13,464,110 outputs
Outputs from Journals of Gerontology Series A: Biological Sciences & Medical Sciences
#16
of 2,457 outputs
Outputs of similar age
#2,280
of 266,267 outputs
Outputs of similar age from Journals of Gerontology Series A: Biological Sciences & Medical Sciences
#1
of 50 outputs
Altmetric has tracked 13,464,110 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,457 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,267 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.