Title |
IL28B and IL10R −1087 polymorphisms are protective for chronic genotype 1 HCV infection and predictors of response to interferon-based therapy in an East-Central European cohort
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Published in |
BMC Research Notes, January 2014
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DOI | 10.1186/1756-0500-7-12 |
Pubmed ID | |
Authors |
Alajos Pár, Gabriella Pár, István Tornai, Ferenc Szalay, Dalma Várszegi, Edit Fráter, Mária Papp, Gabriella Lengyel, János Fehér, Márta Varga, Judit Gervain, János Schuller, Zsuzsanna Nemes, Zoltán Péterfi, Anna Tusnádi, Béla Hunyady, Attila Haragh, Zsolt Szinku, Áron Vincze, László Szereday, Péter Kisfali, Béla Melegh |
Abstract |
Previous studies have shown that single nucleotide polymorphisms (SNP) in IL28B and IL10R are associated with sustained virological response (SVR) in chronic hepatitis C patients treated with pegilated interferon plus ribavirin (P/R). The present study extends our earlier investigations on a large East-Central European cohort. The allele frequencies of IL28B and IL10R in genotype 1 HCV infection were compared with that of healthy controls for the purpose of examining the relationship between the polymorphisms and the SVR to P/R treatment. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 18% |
Student > Doctoral Student | 4 | 14% |
Student > Ph. D. Student | 3 | 11% |
Professor > Associate Professor | 2 | 7% |
Researcher | 2 | 7% |
Other | 4 | 14% |
Unknown | 8 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 43% |
Agricultural and Biological Sciences | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Arts and Humanities | 1 | 4% |
Immunology and Microbiology | 1 | 4% |
Other | 1 | 4% |
Unknown | 8 | 29% |