Title |
Protocol for MInimizing the Risk of Metachronous Adenomas of the CoLorectum with Green Tea Extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population
|
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Published in |
BMC Cancer, August 2011
|
DOI | 10.1186/1471-2407-11-360 |
Pubmed ID | |
Authors |
Julia C Stingl, Thomas Ettrich, Rainer Muche, Martina Wiedom, Jürgen Brockmöller, Angela Seeringer, Thomas Seufferlein |
Abstract |
Prevention of colorectal cancer is a major health care issue. People who have undergone colonoscopy screening and had colorectal polyps removed have a higher risk of being diagnosed with polyps again compared to the normal population. Therefore, it would be ideal to find appropriate means that effectively help to prevent the reoccurrence of polyps after polypectomy. So far, pharmaceutical chemoprevention with NSAIDs including aspirin has been shown to be effective but not gained general acceptance due to side effects. Nutraceuticals such as polyphenols from tea plants have demonstrated remarkable therapeutic and preventive effects in molecular, epidemiological and clinical trials. However, placebo-controlled trials demonstrating the efficacy of nutraceuticals for the (secondary) prevention of colorectal polyps as precursors for colorectal cancer are missing. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Malaysia | 1 | <1% |
United States | 1 | <1% |
Canada | 1 | <1% |
Unknown | 132 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 24 | 18% |
Researcher | 21 | 15% |
Student > Ph. D. Student | 11 | 8% |
Other | 9 | 7% |
Student > Bachelor | 8 | 6% |
Other | 29 | 21% |
Unknown | 34 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 27% |
Agricultural and Biological Sciences | 15 | 11% |
Biochemistry, Genetics and Molecular Biology | 12 | 9% |
Nursing and Health Professions | 9 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 16 | 12% |
Unknown | 42 | 31% |