Title |
Control of tick infestations and pathogen prevalence in cattle and sheep farms vaccinated with the recombinant Subolesin-Major Surface Protein 1a chimeric antigen
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Published in |
Parasites & Vectors, January 2014
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DOI | 10.1186/1756-3305-7-10 |
Pubmed ID | |
Authors |
Alessandra Torina, Juan A Moreno-Cid, Valeria Blanda, Isabel G Fernández de Mera, José M Pérez de la Lastra, Salvatore Scimeca, Marcellocalogero Blanda, Maria Elena Scariano, Salvatore Briganò, Rosaria Disclafani, Antonio Piazza, Joaquín Vicente, Christian Gortázar, Santo Caracappa, Rossella Colomba Lelli, José de la Fuente |
Abstract |
Despite the use of chemical acaricides, tick infestations continue to affect animal health and production worldwide. Tick vaccines have been proposed as a cost-effective and environmentally friendly alternative for tick control. Vaccination with the candidate tick protective antigen, Subolesin (SUB), has been shown experimentally to be effective in controlling vector infestations and pathogen infection. Furthermore, Escherichia coli membranes containing the chimeric antigen composed of SUB fused to Anaplasma marginale Major Surface Protein 1a (MSP1a) (SUB-MSP1a) were produced using a simple low-cost process and proved to be effective for the control of cattle tick, Rhipicephalus (Boophilus) microplus and R. annulatus infestations in pen trials. In this research, field trials were conducted to characterize the effect of vaccination with SUB-MSP1a on tick infestations and the prevalence of tick-borne pathogens in a randomized controlled prospective study. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | 2% |
Australia | 1 | <1% |
Colombia | 1 | <1% |
Mexico | 1 | <1% |
United States | 1 | <1% |
Unknown | 99 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 15% |
Student > Ph. D. Student | 13 | 12% |
Student > Master | 12 | 11% |
Student > Doctoral Student | 9 | 9% |
Student > Bachelor | 9 | 9% |
Other | 25 | 24% |
Unknown | 21 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 38 | 36% |
Veterinary Science and Veterinary Medicine | 15 | 14% |
Biochemistry, Genetics and Molecular Biology | 8 | 8% |
Immunology and Microbiology | 7 | 7% |
Medicine and Dentistry | 7 | 7% |
Other | 6 | 6% |
Unknown | 24 | 23% |